Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-3 of Sigilon Therapeutics Inc. of our report dated March 14, 2022 relating to the financial statements, which appears in Sigilon Therapeutics Inc.'s Annual Report on Form 10-K for the year ended December 31, 2021.  We also consent to the reference to us under the headings “Experts” in such Registration Statement.

/s/ PricewaterhouseCoopers LLP

Boston, Massachusetts

April 14, 2022