Document and Entity Information - USD ($)	12 Months Ended
	Jun. 30, 2021	Dec. 17, 2021	Dec. 31, 2020
Document and Entity Information
Document Type	10-K/A
Document Annual Report	true
Document Transition Report	false
Document Period End Date	Jun. 30, 2021
Entity File Number	001-39727
Entity Registrant Name	SCIENCE 37 HOLDINGS, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	84-4278203
Entity Address, Address Line One	600 Corporate Pointe
Entity Address, Address Line Two	Suite 320
Entity Address, City or Town	Culver City
Entity Address, Country	CA
Entity Address, Postal Zip Code	90230
City Area Code	984
Local Phone Number	377-3737
Title of 12(b) Security	Shares of Common Stock, $0.0001 par value
Trading Symbol	SNCE
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Shell Company	true
Entity Public Float			$ 87,757,186
Entity Common Stock, Shares Outstanding		114,707,150
Entity Central Index Key	0001819113
Current Fiscal Year End Date	--06-30
Document Fiscal Year Focus	2021
Document Fiscal Period Focus	FY
Amendment Flag	true
Amendment Description	Amendment No. 1