<SEC-DOCUMENT>0001104659-23-114985-index.html : 20231107
<SEC-HEADER>0001104659-23-114985.hdr.sgml : 20231107
<ACCEPTANCE-DATETIME>20231107063913
ACCESSION NUMBER:		0001104659-23-114985
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20231107
DATE AS OF CHANGE:		20231107
EFFECTIVENESS DATE:		20231107

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Science 37 Holdings, Inc.
		CENTRAL INDEX KEY:			0001819113
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				844278203
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-275359
		FILM NUMBER:		231381446

	BUSINESS ADDRESS:	
		STREET 1:		800 PARK OFFICES DRIVE
		STREET 2:		SUITE 3606
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709
		BUSINESS PHONE:		(984) 377-3737

	MAIL ADDRESS:	
		STREET 1:		800 PARK OFFICES DRIVE
		STREET 2:		SUITE 3606
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lifesci Acquisition II Corp.
		DATE OF NAME CHANGE:	20200723
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>tm2328650d1_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
Document 1 - file: tm2328650d1_s8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>tm2328650d1_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: tm2328650d1_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>tm2328650d1_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: tm2328650d1_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>tm2328650d1_ex-filingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 4 - file: tm2328650d1_ex-filingfees.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>tm2328650d1_ex5-1img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: tm2328650d1_ex5-1img001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>tm2328650d1_ex5-1img002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: tm2328650d1_ex5-1img002.jpg

</DOCUMENT>
</SEC-DOCUMENT>