<SEC-DOCUMENT>0001104659-23-030589-index.html : 20230309
<SEC-HEADER>0001104659-23-030589.hdr.sgml : 20230309
<ACCEPTANCE-DATETIME>20230309161529
ACCESSION NUMBER:		0001104659-23-030589
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20230309
DATE AS OF CHANGE:		20230309

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Science 37 Holdings, Inc.
		CENTRAL INDEX KEY:			0001819113
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				844278203
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-260828
		FILM NUMBER:		23719925

	BUSINESS ADDRESS:	
		STREET 1:		800 PARK OFFICES DRIVE
		STREET 2:		SUITE 3606
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709
		BUSINESS PHONE:		(984) 377-3737

	MAIL ADDRESS:	
		STREET 1:		800 PARK OFFICES DRIVE
		STREET 2:		SUITE 3606
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lifesci Acquisition II Corp.
		DATE OF NAME CHANGE:	20200723
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>tm239025-1_424b3.htm
<DESCRIPTION>424B3
<TEXT>
Document 1 - file: tm239025-1_424b3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>tm238343d1_posamimg001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: tm238343d1_posamimg001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>tm238343d1_posamimg002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: tm238343d1_posamimg002.jpg

</DOCUMENT>
</SEC-DOCUMENT>