<SEC-DOCUMENT>0001104659-23-028746-index.html : 20230306
<SEC-HEADER>0001104659-23-028746.hdr.sgml : 20230306
<ACCEPTANCE-DATETIME>20230306065017
ACCESSION NUMBER:		0001104659-23-028746
CONFORMED SUBMISSION TYPE:	POS AM
PUBLIC DOCUMENT COUNT:		9
FILED AS OF DATE:		20230306
DATE AS OF CHANGE:		20230306

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Science 37 Holdings, Inc.
		CENTRAL INDEX KEY:			0001819113
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				844278203
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		POS AM
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-260828
		FILM NUMBER:		23707496

	BUSINESS ADDRESS:	
		STREET 1:		600 CORPORATE POINTE
		STREET 2:		SUITE 320
		CITY:			CULVER CITY
		STATE:			CA
		ZIP:			90230
		BUSINESS PHONE:		(984)377-3737

	MAIL ADDRESS:	
		STREET 1:		600 CORPORATE POINTE
		STREET 2:		SUITE 320
		CITY:			CULVER CITY
		STATE:			CA
		ZIP:			90230

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lifesci Acquisition II Corp.
		DATE OF NAME CHANGE:	20200723
</SEC-HEADER>
<DOCUMENT>
<TYPE>POS AM
<SEQUENCE>1
<FILENAME>tm238343d1_posam.htm
<DESCRIPTION>POS AM
<TEXT>
Document 1 - file: tm238343d1_posam.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>tm238343d1_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: tm238343d1_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>tm238343d1_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: tm238343d1_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24.2
<SEQUENCE>4
<FILENAME>tm238343d1_ex24-2.htm
<DESCRIPTION>EXHIBIT 24.2
<TEXT>
Document 4 - file: tm238343d1_ex24-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>tm238343d1_ex5-1img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: tm238343d1_ex5-1img001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>tm238343d1_ex5-1img002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: tm238343d1_ex5-1img002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>tm238343d1_ex5-1img003.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: tm238343d1_ex5-1img003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>tm238343d1_posamimg001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: tm238343d1_posamimg001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>tm238343d1_posamimg002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 9 - file: tm238343d1_posamimg002.jpg

</DOCUMENT>
</SEC-DOCUMENT>