Cover	12 Months Ended
	Dec. 31, 2021
Cover [Abstract]
Document Type	POS AM
Entity Registrant Name	Science 37 Holdings, Inc.
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Central Index Key	0001819113
Amendment Flag	true
Amendment Description	POST-EFFECTIVE AMENDMENT NO. 2