<SEC-DOCUMENT>0001104659-22-017309-index.html : 20220210
<SEC-HEADER>0001104659-22-017309.hdr.sgml : 20220210
<ACCEPTANCE-DATETIME>20220209201156
ACCESSION NUMBER:		0001104659-22-017309
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20220210
DATE AS OF CHANGE:		20220209

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Science 37 Holdings, Inc.
		CENTRAL INDEX KEY:			0001819113
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				844278203
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-260828
		FILM NUMBER:		22609113

	BUSINESS ADDRESS:	
		STREET 1:		600 CORPORATE POINTE
		STREET 2:		SUITE 320
		CITY:			CULVER CITY
		STATE:			CA
		ZIP:			90230
		BUSINESS PHONE:		(984)377-3737

	MAIL ADDRESS:	
		STREET 1:		600 CORPORATE POINTE
		STREET 2:		SUITE 320
		CITY:			CULVER CITY
		STATE:			CA
		ZIP:			90230

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lifesci Acquisition II Corp.
		DATE OF NAME CHANGE:	20200723
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>tm2131243-9_424b3.htm
<DESCRIPTION>424B3
<TEXT>
Document 1 - file: tm2131243-9_424b3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>lg_science-4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: lg_science-4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>tm2131243d1-fc_trial4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: tm2131243d1-fc_trial4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>tm2131243d1-fc_decent4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: tm2131243d1-fc_decent4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>tm2131243d1-pc_market4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: tm2131243d1-pc_market4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>tm2131243d1-fc_dct4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: tm2131243d1-fc_dct4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>tm2131243d1-fc_agile4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: tm2131243d1-fc_agile4clr.jpg

</DOCUMENT>
</SEC-DOCUMENT>