Exhibit 107.1

Calculation of Fee Filing Tables
Form S-3
(Form Type)

Sema4 Holdings Corp.
(Exact name of Registration as Specified in its Charter)

Table 1 – Newly Registered and Carry Forward Securities

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward

Newly Registered Securities

Fees to be Paid

Equity

Class A Common stock, par value $0.0001 per share

457(o)

Equity

Preferred stock, par value $0.0001 per share

457(o)

Debt

Debt securities

457(o)

Other

Warrants

457(o)

Other

Subscription Rights

457(o)

Other

Units

457(o)

Unallocated (Universal) Shelf

—

457(o)

$300,000,000(1)

N/A(2)

$300,000,000

$0.0000927

$27,810

Fees Previously Paid

—

—

—

—

—

—

—

Carry Forward Securities

Carry Forward Securities

—

—

—

—

—

—

—

—

—

Total Offering Amounts

$300,000,000

$27,810

Total Fees Previously Paid

—

Total Fee Offsets

—

Net Fee Due

$27,810

(1)

There is being registered hereunder an unspecified number of shares of (a) Class A common stock (“Class A common stock”), (b) preferred stock, (c) debt securities, (d) warrants to purchase Class A common stock, preferred stock or debt securities of the Registrant, (e) subscription rights to purchase common stock, preferred stock or debt securities of the Registrant, and (f) units, consisting of some or all of these securities in any combination, as may be sold from time to time by the Registrant. Any securities registered hereunder may be sold separately or as units with other securities registered hereunder. There is also being registered hereunder an unspecified number of shares of Class A common stock, preferred stock and debt securities as shall be issuable upon conversion, exchange or exercise of any securities that provide for such issuance. In no event will the aggregate offering price of all types of securities issued by the Registrant pursuant to this registration statement exceed $300,000,000. Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement also covers any additional securities that may be offered or issued in connection with any stock split, stock dividend or similar transaction.

(2)

The proposed maximum offering price per share and proposed maximum aggregate offering price for each type of security will be determined from time to time by the Registrant in connection with the issuance by the Registrant of the securities registered hereunder and is not specified as to each class of security pursuant to General Instruction II.D. of Form S-3 under the Securities Act.

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