The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89bio Inc EQUITIES 282559103   1,772,891 158,719 SH   SOLE   158,719 0 0
Akero Therapeutics Inc EQUITIES 00973Y108   5,820,081 249,254 SH   SOLE   249,254 0 0
Aligos Therapeutics Inc EQUITIES 01626L105   443,892 668,512 SH   SOLE   668,512 0 0
Alpine Immune Sciences Inc EQUITIES 02083G100   5,675,858 297,789 SH   SOLE   297,789 0 0
Altimmune Inc EQUITIES 02155H200   1,687,500 150,000 SH   SOLE   150,000 0 0
Annexon Inc EQUITIES 03589W102   1,895,128 417,429 SH   SOLE   417,429 0 0
Apellis Pharmaceuticals Inc EQUITIES 03753U106   598,600 10,000 SH   SOLE   10,000 0 0
BioCryst Pharmaceuticals Inc EQUITIES 09058V103   1,489,881 248,728 SH   SOLE   248,728 0 0
Biogen Idec Inc EQUITIES 09062X103   5,175,400 20,000 SH   SOLE   20,000 0 0
Biohaven Ltd EQUITIES G1110E107   3,025,746 70,695 SH   SOLE   70,695 0 0
Caribou Biosciences Inc EQUITIES 142038108   5,161,687 900,818 SH   SOLE   900,818 0 0
Celldex Therapeutics Inc EQUITIES 15117B202   9,804,547 247,215 SH   SOLE   247,215 0 0
Cerus Corp EQUITIES 157085101   3,239,678 1,499,851 SH   SOLE   1,499,851 0 0
Cogent Biosciences Inc EQUITIES 19240Q201   5,684,478 966,748 SH   SOLE   966,748 0 0
Compugen Ltd EQUITIES M25722105   1,861,200 940,000 SH   SOLE   940,000 0 0
CymaBay Therapeutics Inc EQUITIES 23257D103   5,172,190 218,975 SH   SOLE   218,975 0 0
DexCom Inc EQUITIES 252131107   3,846,790 31,000 SH   SOLE   31,000 0 0
Evogene Ltd EQUITIES M4119S104   2,604,000 3,100,000 SH   SOLE   3,100,000 0 0
Gossamer Bio Inc EQUITIES 38341P102   5,593,870 6,130,268 SH   SOLE   6,130,268 0 0
Immunovant Inc EQUITIES 45258J102   842,600 20,000 SH   SOLE   20,000 0 0
Insmed Inc EQUITIES 457669307   4,819,069 155,504 SH   SOLE   155,504 0 0
Intellia Therapeutics Inc EQUITIES 45826J105   1,671,523 54,822 SH   SOLE   54,822 0 0
Intra-Cellular Therapies Inc EQUITIES 46116X101   5,729,600 80,000 SH   SOLE   80,000 0 0
Intuitive Surgical Inc EQUITIES 46120E602   5,332,987 15,808 SH   SOLE   15,808 0 0
KalVista Pharmaceuticals Inc LONG OPTION CALLS 483497103   2,209,900 180,400 SH Call SOLE   180,400 0 0
KalVista Pharmaceuticals Inc EQUITIES 483497103   1,368,742 111,734 SH   SOLE   111,734 0 0
Karyopharm Therapeutics Inc EQUITIES 48576U106   486,091 561,955 SH   SOLE   561,955 0 0
Kodiak Sciences Inc EQUITIES 50015M109   3,040,000 1,000,000 SH   SOLE   1,000,000 0 0
MacroGenics Inc EQUITIES 556099109   12,108,126 1,258,641 SH   SOLE   1,258,641 0 0
Medtronic PLC EQUITIES G5960L103   11,121,300 135,000 SH   SOLE   135,000 0 0
Mersana Therapeutics Inc LONG OPTION CALLS 59045L106   699,712 301,600 SH Call SOLE   301,600 0 0
Mersana Therapeutics Inc EQUITIES 59045L106   14,894,716 6,420,136 SH   SOLE   6,420,136 0 0
Merus NV EQUITIES N5749R100   17,753,478 645,581 SH   SOLE   645,581 0 0
Mirati Therapeutics Inc LONG OPTION CALLS 60468T105   8,812,500 150,000 SH Call SOLE   150,000 0 0
Mirum Pharmaceuticals Inc EQUITIES 604749101   2,385,541 80,811 SH   SOLE   80,811 0 0
Molecular Templates Inc EQUITIES 608550208   1,322,688 354,608 SH   SOLE   354,608 0 0
MoonLake Immunotherapeutics EQUITIES 61559X104   3,019,500 50,000 SH   SOLE   50,000 0 0
Morphic Holding Inc EQUITIES 61775R105   14,441,213 500,042 SH   SOLE   500,042 0 0
Nuvalent Inc EQUITIES 670703107   14,202,870 193,000 SH   SOLE   193,000 0 0
Olema Pharmaceuticals Inc EQUITIES 68062P106   8,050,835 573,830 SH   SOLE   573,830 0 0
Oric Pharmaceuticals Inc EQUITIES 68622P109   10,764,000 1,170,000 SH   SOLE   1,170,000 0 0
Penumbra Inc EQUITIES 70975L107   5,030,800 20,000 SH   SOLE   20,000 0 0
Pliant Therapeutics Inc EQUITIES 729139105   5,768,470 318,524 SH   SOLE   318,524 0 0
Pmv Pharmaceuticals Inc EQUITIES 69353Y103   1,705,000 550,000 SH   SOLE   550,000 0 0
Poseida Therapeutics Inc EQUITIES 73730P108   12,451,417 3,705,779 SH   SOLE   3,705,779 0 0
Praxis Precision Medicines Inc EQUITIES 74006W207   6,323,977 283,841 SH   SOLE   283,841 0 0
Relmada Therapeutics Inc EQUITIES 75955J402   414,000 100,000 SH   SOLE   100,000 0 0
Rezolute Inc EQUITIES 76200L309   155,907 157,085 SH   SOLE   157,085 0 0
Rhythm Pharmaceuticals Inc EQUITIES 76243J105   8,010,181 174,248 SH   SOLE   174,248 0 0
Rocket Pharmaceuticals Inc EQUITIES 77313F106   11,468,680 382,672 SH   SOLE   382,672 0 0
Rocket Pharmaceuticals Inc Wts WARRANTS 77313F114   51,366 104,828 SH   SOLE   104,828 0 0
Sanofi SA EQUITIES 80105N105   10,940,600 220,000 SH   SOLE   220,000 0 0
Sarepta Therapeutics Inc EQUITIES 803607100   4,521,024 46,884 SH   SOLE   46,884 0 0
Scholar Rock Holding Corp EQUITIES 80706P103   5,076,000 270,000 SH   SOLE   270,000 0 0
Schrodinger Inc EQUITIES 80810D103   1,113,989 31,117 SH   SOLE   31,117 0 0
Soleno Therapeutics Inc EQUITIES 834203309   2,965,016 73,665 SH   SOLE   73,665 0 0
Solid Biosciences Inc EQUITIES 83422E204   3,652,410 594,855 SH   SOLE   594,855 0 0
Tela Bio Inc EQUITIES 872381108   5,263,430 795,080 SH   SOLE   795,080 0 0
Terns Pharmaceuticals Inc EQUITIES 880881107   3,355,324 516,999 SH   SOLE   516,999 0 0
Trevi Therapeutics Inc EQUITIES 89532M101   1,157,603 863,883 SH   SOLE   863,883 0 0
United Therapeutics Corp EQUITIES 91307C102   3,597,400 16,360 SH   SOLE   16,360 0 0
Urogen Pharma Ltd EQUITIES M96088105   7,881,060 525,404 SH   SOLE   525,404 0 0
Veracyte Inc EQUITIES 92337F107   6,814,860 247,723 SH   SOLE   247,723 0 0
Viridian Therapeutics Inc EQUITIES 92790C104   1,098,540 50,438 SH   SOLE   50,438 0 0
Xenon Pharmaceuticals Inc EQUITIES 98420N105   7,515,518 163,168 SH   SOLE   163,168 0 0
Zura Bio Ltd EQUITIES G9TY5A101   2,162,196 462,997 SH   SOLE   462,997 0 0
argenx SE EQUITIES 04016X101   1,835,955 4,826 SH   SOLE   4,826 0 0