The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89bio Inc EQUITIES 282559103   930,214 60,247 SH   SOLE   60,247 0 0
Acelyrin Inc LONG OPTION PUTS 00445A100   233,910 23,000 SH Put SOLE   23,000 0 0
Aclaris Therapeutics Inc LONG OPTION CALLS 00461U105   1,363,150 199,000 SH Call SOLE   199,000 0 0
Aclaris Therapeutics Inc LONG OPTION PUTS 00461U105   16,440 2,400 SH Put SOLE   2,400 0 0
Aerovate Therapeutics Inc EQUITIES 008064107   1,357,000 100,000 SH   SOLE   100,000 0 0
Akero Therapeutics Inc LONG OPTION CALLS 00973Y108   10,116,000 200,000 SH Call SOLE   200,000 0 0
Akero Therapeutics Inc LONG OPTION PUTS 00973Y108   5,391,828 106,600 SH Put SOLE   106,600 0 0
Akero Therapeutics Inc EQUITIES 00973Y108   1,584,975 31,336 SH   SOLE   31,336 0 0
Aligos Therapeutics Inc EQUITIES 01626L105   472,020 631,887 SH   SOLE   631,887 0 0
Alkermes Plc EQUITIES G01767105   1,161,155 41,455 SH   SOLE   41,455 0 0
Annexon Inc EQUITIES 03589W102   943,330 399,716 SH   SOLE   399,716 0 0
BioCryst Pharmaceuticals Inc EQUITIES 09058V103   5,605,031 791,671 SH   SOLE   791,671 0 0
BioMarin Pharmaceutical Inc EQUITIES 09061G101   884,800 10,000 SH   SOLE   10,000 0 0
Biogen Idec Inc EQUITIES 09062X103   7,214,014 28,069 SH   SOLE   28,069 0 0
Biohaven Ltd EQUITIES G1110E107   260,100 10,000 SH   SOLE   10,000 0 0
Caribou Biosciences Inc EQUITIES 142038108   4,267,517 892,786 SH   SOLE   892,786 0 0
Cerus Corp EQUITIES 157085101   1,950,302 1,203,890 SH   SOLE   1,203,890 0 0
Clene Inc EQUITIES 185634102   247,950 500,000 SH   SOLE   500,000 0 0
Cogent Biosciences Inc EQUITIES 19240Q201   6,350,877 651,372 SH   SOLE   651,372 0 0
Compugen Ltd EQUITIES M25722105   325,675 350,188 SH   SOLE   350,188 0 0
Crinetics Pharmaceuticals Inc EQUITIES 22663K107   6,542,800 220,000 SH   SOLE   220,000 0 0
CymaBay Therapeutics Inc LONG OPTION CALLS 23257D103   2,982,000 200,000 SH Call SOLE   200,000 0 0
CymaBay Therapeutics Inc EQUITIES 23257D103   8,796,900 590,000 SH   SOLE   590,000 0 0
Eliem Therapeutics Inc EQUITIES 28658R106   318,519 121,110 SH   SOLE   121,110 0 0
Eloxx Pharmaceuticals Inc EQUITIES 29014R202   260,101 54,075 SH   SOLE   54,075 0 0
Evogene Ltd EQUITIES M4119S104   1,818,150 3,100,000 SH   SOLE   3,100,000 0 0
Gilead Sciences Inc EQUITIES 375558103   4,705,408 62,789 SH   SOLE   62,789 0 0
Gossamer Bio Inc EQUITIES 38341P102   5,105,287 6,130,268 SH   SOLE   6,130,268 0 0
Humana Inc EQUITIES 444859102   4,865,200 10,000 SH   SOLE   10,000 0 0
ImmunoGen Inc LONG OPTION CALLS 45253H101   3,967,500 250,000 SH Call SOLE   250,000 0 0
ImmunoGen Inc EQUITIES 45253H101   20,748,993 1,307,435 SH   SOLE   1,307,435 0 0
Insmed Inc EQUITIES 457669307   3,797,272 150,387 SH   SOLE   150,387 0 0
Intellia Therapeutics Inc EQUITIES 45826J105   1,676,429 53,018 SH   SOLE   53,018 0 0
Intra-Cellular Therapies Inc EQUITIES 46116X101   10,872,746 208,730 SH   SOLE   208,730 0 0
KalVista Pharmaceuticals Inc LONG OPTION CALLS 483497103   5,107,752 530,400 SH Call SOLE   530,400 0 0
KalVista Pharmaceuticals Inc EQUITIES 483497103   2,204,634 228,934 SH   SOLE   228,934 0 0
Karyopharm Therapeutics Inc EQUITIES 48576U106   753,020 561,955 SH   SOLE   561,955 0 0
Kodiak Sciences Inc EQUITIES 50015M109   2,006,030 1,114,461 SH   SOLE   1,114,461 0 0
Krystal Biotech Inc EQUITIES 501147102   8,297,596 71,531 SH   SOLE   71,531 0 0
MacroGenics Inc EQUITIES 556099109   5,890,976 1,264,158 SH   SOLE   1,264,158 0 0
Mersana Therapeutics Inc LONG OPTION CALLS 59045L106   1,018,032 801,600 SH Call SOLE   801,600 0 0
Mersana Therapeutics Inc EQUITIES 59045L106   6,350,000 5,000,000 SH   SOLE   5,000,000 0 0
Merus NV EQUITIES N5749R100   11,790,000 500,000 SH   SOLE   500,000 0 0
Mirati Therapeutics Inc LONG OPTION CALLS 60468T105   6,534,000 150,000 SH Call SOLE   150,000 0 0
Mirati Therapeutics Inc EQUITIES 60468T105   8,712,000 200,000 SH   SOLE   200,000 0 0
Mirum Pharmaceuticals Inc EQUITIES 604749101   3,479,602 110,114 SH   SOLE   110,114 0 0
Molecular Templates Inc EQUITIES 608550208   2,241,123 354,608 SH   SOLE   354,608 0 0
Morphic Holding Inc EQUITIES 61775R105   13,535,892 590,829 SH   SOLE   590,829 0 0
Novo Nordisk A/S EQUITIES 670100205   5,456,400 60,000 SH   SOLE   60,000 0 0
Olema Pharmaceuticals Inc EQUITIES 68062P106   5,036,342 407,801 SH   SOLE   407,801 0 0
Oric Pharmaceuticals Inc EQUITIES 68622P109   6,796,237 1,123,345 SH   SOLE   1,123,345 0 0
Pliant Therapeutics Inc EQUITIES 729139105   4,342,092 250,409 SH   SOLE   250,409 0 0
Point Biopharma Global Inc EQUITIES 730541109   624,979 93,700 SH   SOLE   93,700 0 0
Poseida Therapeutics Inc EQUITIES 73730P108   8,491,804 3,567,985 SH   SOLE   3,567,985 0 0
Praxis Precision Medicines Inc EQUITIES 74006W108   7,041,643 4,117,920 SH   SOLE   4,117,920 0 0
Prothena Corporation PLC EQUITIES G72800108   1,284,849 26,629 SH   SOLE   26,629 0 0
Relmada Therapeutics Inc EQUITIES 75955J402   300,000 100,000 SH   SOLE   100,000 0 0
Reviva Pharmaceuticals Holdings Inc LONG OPTION PUTS 76152G100   2,752,320 564,000 SH Put SOLE   564,000 0 0
Rezolute Inc EQUITIES 76200L309   571,877 433,240 SH   SOLE   433,240 0 0
Rhythm Pharmaceuticals Inc EQUITIES 76243J105   5,972,811 260,537 SH   SOLE   260,537 0 0
Rocket Pharmaceuticals Inc Wts WARRANTS 77313F114   17,821 104,828 SH   SOLE   104,828 0 0
Roivant Sciences Ltd EQUITIES G76279101   1,168,000 100,000 SH   SOLE   100,000 0 0
SPRD S&P Biotech ETF LONG OPTION CALLS 78464A870   21,906,000 300,000 SH Call SOLE   300,000 0 0
Sagimet Biosciences Inc EQUITIES 786700104   880,000 100,000 SH   SOLE   100,000 0 0
Sarepta Therapeutics Inc EQUITIES 803607100   1,114,860 9,197 SH   SOLE   9,197 0 0
Scholar Rock Holding Corp EQUITIES 80706P103   68,948 9,711 SH   SOLE   9,711 0 0
Schrodinger Inc EQUITIES 80810D103   856,892 30,311 SH   SOLE   30,311 0 0
Soleno Therapeutics Inc EQUITIES 834203309   10,918,700 370,000 SH   SOLE   370,000 0 0
Syndax Pharmaceuticals Inc EQUITIES 87164F105   290,400 20,000 SH   SOLE   20,000 0 0
Tela Bio Inc EQUITIES 872381108   3,923,768 490,471 SH   SOLE   490,471 0 0
Terns Pharmaceuticals Inc EQUITIES 880881107   2,515,000 500,000 SH   SOLE   500,000 0 0
Trevi Therapeutics Inc EQUITIES 89532M101   2,021,765 927,415 SH   SOLE   927,415 0 0
United Therapeutics Corp EQUITIES 91307C102   7,097,739 31,424 SH   SOLE   31,424 0 0
Urogen Pharma Ltd EQUITIES M96088105   7,129,451 508,883 SH   SOLE   508,883 0 0
Veracyte Inc EQUITIES 92337F107   5,349,620 239,571 SH   SOLE   239,571 0 0
Vertex Pharmaceuticals Inc EQUITIES 92532F100   4,786,641 13,765 SH   SOLE   13,765 0 0
Viridian Therapeutics Inc EQUITIES 92790C104   727,699 47,438 SH   SOLE   47,438 0 0
Voyager Therapeutics Inc EQUITIES 92915B106   805,737 103,966 SH   SOLE   103,966 0 0
Xenon Pharmaceuticals Inc EQUITIES 98420N105   1,844,503 53,996 SH   SOLE   53,996 0 0
Zura Bio Ltd EQUITIES G9TY5A101   2,666,664 404,040 SH   SOLE   404,040 0 0