April 8, 2024

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-3720

Attention: Chris Edwards

Re:	LENZ Therapeutics, Inc.
	Registration Statement on Form S-1
	File No. 333-278393

Acceleration Request

Requested Date:	April 10, 2024
Requested Time:	4:00 p.m. Eastern Time, or as soon thereafter as practicable

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, LENZ Therapeutics, Inc. (the “Company”) hereby requests that its Registration Statement on Form S-1 (File No. 333-278393) (the “Registration Statement”) be declared effective at the “Requested Date” and “Requested Time” set forth above or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Wilson Sonsini Goodrich & Rosati, P.C., by calling Ben Capps at (858) 350-2237.

Sincerely,
LENZ THERAPEUTICS, INC.
By:	/s/ Evert Schimmelpennink
	Evert Schimmelpennink
	Chief Executive Officer

cc:	Daniel Chevallard, LENZ Therapeutics, Inc.
	Dan Koeppen, Wilson Sonsini Goodrich & Rosati
	Ben Capps, Wilson Sonsini Goodrich & Rosati