424B3 1 d148597d424b3.htm 424B3 424B3

Filed Pursuant to Rule 424(b)(3)

Registration No. 333-249020

PROSPECTUS SUPPLEMENT NO. 1

(to Prospectus dated October 16, 2020)

 

LOGO

This prospectus supplement supplements the prospectus dated October 16, 2020 (the “Prospectus”), which forms a part of Opthea Limited’s registration statement on Form F-1 (File No. 333-249020). This prospectus supplement is being filed to update and supplement the information in the Prospectus with the information contained in our half-year financial report 31 December 2020, prepared in accordance with Listing Rule 4.2A of the Australian Securities Exchange, or the Half-Year Report, filed with the Securities and Exchange Commission on February 22, 2021 as Exhibit 99.1 to our Report on Form 6-K. Accordingly, we have attached the Half-Year Report to this prospectus supplement.

The Prospectus and this prospectus supplement relate in part to the offer and sale from time to time by the holders of certain pre-funded warrants to purchase 936,700 American depositary shares, or ADSs, representing 7,493,600 ordinary shares of Opthea Limited. Each pre-funded warrant will be exercisable for one ADS. Each ADS represents eight ordinary shares, no par value, deposited with The Bank of New York Mellon, as depositary. The pre-funded warrants may be exercised at any time until all of the pre-funded warrants are exercised in full, subject to certain conditions under Australian law set forth in the Prospectus.

Our ordinary shares are listed on the Australian Securities Exchange under the symbol “OPT,” and our ADSs are listed on the Nasdaq Global Select Market under the symbol “OPT.” On February 19, 2021, the last reported sale price of our ordinary shares on the Australian Securities Exchange was A$1.75 per ordinary share, equivalent to a price of US$10.88 per ADS, after giving effect to the Australian dollar/U.S. dollar exchange rate of A$1.287 to US$1.00 as of February 19, 2021, and an ADS-to-ordinary share ratio of 1-to-8. On February 19, 2021, the last reported sale price of our ADSs on the Nasdaq Global Select Market was US$11.18 per ADS.

There is no established public trading market for the pre-funded warrants, and we do not expect a market to develop. In addition, we have not applied, and do not intend to apply, for a listing of the pre-funded warrants on any national securities exchange or other nationally recognized trading system.

This prospectus supplement should be read in conjunction with the Prospectus, which is to be delivered with this prospectus supplement. This prospectus supplement is qualified by reference to the Prospectus, except to the extent that the information in this prospectus supplement updates and supersedes the information contained in the Prospectus.

This prospectus supplement is not complete without, and may not be delivered or utilized except in connection with, the Prospectus.

Investing in our securities involves a high degree of risk. See “Risk Factors” beginning on page 12 of the Prospectus.

We are an “emerging growth company” as that term is used in the Jumpstart Our Business Startups Act of 2012 and, as such, have elected to comply with certain reduced public company reporting requirements.

Neither the U.S. Securities and Exchange Commission nor any U.S. state securities commission has approved or disapproved of these securities or determined if this prospectus supplement or the accompanying Prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

Prospectus Supplement dated February 22, 2021


 

LOGO

22 February 2021

HALF-YEAR FINANCIAL REPORT 31 DECEMBER 2020

In accordance with Listing Rule 4.2A, we enclose the Half-Year Financial Report (reviewed) on the consolidated results of Opthea Limited (‘Opthea’ or ‘Group’) for the half-year ended 31 December 2020. The previous corresponding periods are the financial year ended 30 June 2020 and the half-year ended 31 December 2019.

Information in relation to the operational performance, financial performance, cash flows and financial position is included in the attached Appendix 4D Half-Year Financial Report.

This Half-Year Financial Report should be read in conjunction with the Company’s Annual Report for the year ended 30 June 2020.

 

 

LOGO

Mike Tonroe

Company Secretary

 

Level 4, 650 Chapel Street, South Yarra, Victoria 3141 Australia T +61 (3) 9826 0399

www.opthea.com ABN 32 006 340 567


LOGO

APPENDIX 4D

HALF-YEAR FINANCIAL REPORT

OPTHEA LIMITED

ABN 32 006 340 567

REPORTING PERIOD: HALF-YEAR ENDED 31 DECEMBER 2020

PREVIOUS CORRESPONDING PERIOD: HALF-YEAR ENDED 31 DECEMBER 2019

INDEX

 

1. Results for announcement to the market

   next page

2. Financial report:

  

    Directors’ Report

   page 1 of the financial report

    Auditor’s Independence Declaration

   page 4 of the financial report

    Financial Statements

   pages 5–15 of the financial report

    Directors’ Declaration

   page 16 of the financial report

    Independent Auditor’s Review Report

   page 17 of the financial report

This half-year report is to be read in conjunction with the Company’s 2020 Annual Report

Note: The financial figures provided are in Australian dollars.

ASX Announcement

22 February 2021


 

      O p t h e a     |     A P P E N D I X    4 D

  

 

iii

 

RESULTS FOR ANNOUNCEMENT TO THE MARKET

The consolidated results of Opthea Limited for the six months ended 31 December 2020 are as follows:

Revenues and results from ordinary activities

 

     

Change compared to:

31/12/2019

         31/12/2020    
              %                $        

Revenues from ordinary activities

     Increased      15            to      314,295        

Loss from ordinary activities before tax

     Loss has increased                      236         to      38,505,045        

Loss from ordinary activities after tax attributable to members

     Loss has increased      359         to      34,982,213        

An explanation of the figures reported above are contained in the Directors’ Report under the heading ‘Financial performance’.

SHAREHOLDER DISTRIBUTIONS

No dividends have been paid or declared by the entity since the beginning of the current reporting period.

 

      Consolidated  

NTA backing

     31/12/2020        30/06/2020    

Net tangible asset backing per ordinary security

     $0.59        $0.24    

STATUS OF REVIEW OF ACCOUNTS

The financial report for the half-year ended 31 December 2020 has been reviewed. The auditor’s review report is included at page 17 of the financial report.


LOGO

 

Opthea Limited and Controlled Entity ABN 32 006 340 567 Half Year Report for the half-year ended 31 December 2020 OUR TOMORROW STARTS TODAY


LOGO

 

WITHIN SIGHT CONTENTS 1 Directors’ Report 4 Auditor’s Independence Declaration 5 Condensed Consolidated Statement of Profit or Loss and Other Comprehensive Income for the Half-Year Ended 31 December 2020 6 Condensed Consolidated Statement of Financial Position as at 31 December 2020 7 Condensed Consolidated Statement of Changes in Equity for the Half-Year Ended 31 December 2020 8 Condensed Consolidated Statement of Cash Flows for the Half-Year Ended 31 December 2020 9 Notes to the Condensed Consolidated Financial Statements for the Half-Year Ended 31 December 2020 16 Directors’ Declaration 17 Independent Auditor’s Review Report TO IMPROVE THE VISION OF MILLIONS


 

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1

 

D I R E C T O R S ’   R E P O R T

The directors of Opthea Limited submit herewith the financial report of Opthea Limited and its subsidiaries (Opthea, the Company and the Group) for the half-year ended 31 December 2020. In order to comply with the provisions of the Corporations Act 2001, the directors report as follows:

D I R E C T O R S

The names of the Company’s Directors in office during the half-year and until the date of this report are:

 

Jeremy Levin

 

 

Chairman, Non-Executive Director (appointed on 12 October 2020)

 

Geoffrey Kempler

 

 

Chairman, Non-Executive Director (retired on 12 October 2020)

 

Megan Baldwin

 

 

Chief Executive Officer and Managing Director

 

Michael Sistenich

 

 

Non-Executive Director

 

Lawrence Gozlan

 

 

Non-Executive Director (appointed on 24 July 2020)

 

Dan Spiegelman

 

 

Non-Executive Director (appointed on 10 September 2020)

 

 

O P E R A T I N G   A N D   F I N A N C I A L   R E V I E W

Financial performance

For the half-year ended 31 December 2020, the Company’s net loss before tax attributable to members is $38,505,045 (31 December 2019: $11,465,210). The increased loss compared to the prior year is mainly due to the increase in research and development (R&D) spending, which can be attributed to the manufacturing of OPT-302 and planning of the Phase 3 clinical trials of OPT-302 in wet AMD.

Set out below are other factors affecting financial performance:

 

/

The total investment in R&D was $18,807,475 (31 December 2019: $8,340,640);

 

/

Net foreign exchange losses were $12,442,849 (31 December 2019: gain of $113,370);

 

/

The net income tax benefit for the half year is $3,522,832 (31 December 2019: $3,845,192); and

 

/

Basic earnings per share were a loss of 11.75 cents (31 December 2019: loss of 3.02 cents).

Financial position

Points to note on the Company’s financial position are:

 

/

The cash position as at 31 December 2020 was $202,544,985 (30 June 2020: $62,020,382);

 

/

The 2020 Research and Development (R&D) tax incentive claim of $8,533,123 was received from the Australian Tax Office during October 2020. A benefit of $3,522,832 (31 December 2019: $3,845,192) has been recognised in relation to the R&D tax incentive in the current period and included in current tax assets;

 

/

During the half year to 31 December 2020, 68,506,400 (31 December 2019: 18,867,930) new shares were issued in a US initial public offering (IPO) and NASDAQ listing, increasing contributed equity by $148,623,205 (31 December 2019: $48,722,444). The Company also issued 7,493,600 pre-funded warrants in the IPO, increasing contributed equity by $16,268,932; and

 

/

As at 31 December 2020, the Net Tangible Asset backing per share was 59 cents (30 June 2020: 24 cents).

Opthea: Company Overview

Opthea is committed to the development of new therapies for the treatment of serious eye diseases that affect the back-of-the-eye, or retina, and lead to vision loss.

Wet (neovascular) age-related macular degeneration (wet AMD) is a progressive, chronic disease of the central retina and in developed nations, is the leading cause of visual impairment in the elderly. Wet AMD is associated with blood vessel dysfunction and proliferation in the macula, a region of the retina which is needed for sharp, central vision. New blood vessels break through layers of the retinal tissue, leaking fluid, lipids and blood, leading to fibrous scarring and loss of vision. Vision loss associated with wet AMD can be rapid and is generally severe, impacting patient independence and contributing to significant healthcare and economic costs worldwide.

Although the underlying cause and biology of wet AMD is complex, inhibition of vascular endothelial growth factor-A, or VEGF-A, has been shown to play an important role in the growth and leakage of vessels associated with the disease, and inhibitors of VEGF-A are now standard of care treatments for wet AMD. The VEGF-A inhibitors ranibizumab (Lucentis®) and aflibercept (Eylea®), approved for the treatment of wet AMD, together generated revenues in excess of 11 billion USD in 2019. Such commercial success reflects the widespread use of the VEGF-A inhibitor class of therapies and the importance that physicians and patients alike attribute to the preservation and improvement of visual acuity for quality of life.

However, despite many patients experiencing gains or stabilisation of vision, at least 45% of patients with wet AMD exhibit a suboptimal response to therapies that selectively target VEGF-A. As such, there remains a very large commercial opportunity for novel therapies that address the unmet medical need for patients who have further room for improvement in visual acuity despite regular administration of currently available therapies.

 


    2

 

DIRECTORS’ REPORT (CONT.)

 

OPT-302: Opthea’s Phase 3 ready candidate for the treatment of Wet AMD

Approved therapies for wet AMD block VEGF-A, whereas OPT-302 targets alternative members of the VEGF family of proteins, namely VEGF-C and VEGF-D, that also stimulate blood vessel growth and vascular leakage and are implicated in the progression of retinal diseases.

Opthea is developing OPT-302 as a complementary treatment to be used in conjunction with VEGF-A inhibitors for the treatment of wet AMD and other retinal diseases. By combining administration of OPT-302 with a VEGF-A inhibitor, broader blockade of important signalling pathways that contribute to the pathophysiology of retinal diseases can be achieved, which may improve visual acuity and retinal swelling in patients. In addition, inhibition of VEGF-A results in compensatory upregulation of VEGF-C and VEGF-D that may limit the efficacy of selective VEGF-A inhibitors. OPT-302 blocks this mechanism of resistance to existing therapies which may then result in improved and more durable clinical responses.

Opthea’s lead product candidate OPT-302 is well-differentiated with a key objective to improve clinical efficacy and the potential to also produce more sustained, durable clinical outcomes for patients. The majority of agents currently in clinical development are seeking to reduce the frequency of patient treatments, rather than provide superior vision gains for those affected by retinal diseases.

With a scarcity of combination therapies in development that may offer improved outcomes for retinal disease patients, and with positive Phase 2b data in wet AMD, OPT-302 is a promising drug candidate with large commercial potential as it advances into the final stage of clinical development, Phase 3 pivotal studies.

O P E R A T I O N A L   U P D A T E

Despite the challenges posed by the events of 2020, for Opthea Limited the past 6 months has been one of scientific and financial validation.

In respect of our science, the company successfully completed End-of-Phase 2 meetings with the U.S. Food and Drug Administration (FDA), and a Scientific Advice meeting with the European Medicines Agency (EMA). The regulatory engagement provided Opthea with guidance on our Phase 3 clinical program for OPT-302 in wet AMD and a clear regulatory pathway to support filing for marketing approvals in the US and Europe. Following the agreement by the FDA and EMA on key aspects of the proposed Phase 3 clinical trial designs, the design of two concurrent, global, multicentre, randomised, sham-controlled trials evaluating OPT-302 in combination with either ranibizumab (the ShORe trial) or aflibercept (the COAST trial), were finalised.

ShORe and COAST will enrol treatment-naïve patients and assess the efficacy and safety of 2.0 mg of OPT-302 in combination with ranibizumab or aflibercept, compared to ranibizumab or aflibercept monotherapy in each respective trial. In addition, to understand the durability of OPT-302 treatment effect with less frequent dosing, each trial will compare the clinical efficacy of OPT-302 administered in combination with the applicable VEGF-A inhibitor on an every four-week and every eight-week dosing regimen. The ShORe and COAST Phase 3 trials build upon and maintain key features of our successful Phase 2b clinical trial of OPT-302 combination therapy for the treatment of wet AMD, while evaluating the administration of OPT-302 combination therapy over a longer treatment period and in a greater number of patients.

Patient recruitment in the Phase 3 trials is on-track to initiate in the 1Q CY 2021 and topline data is expected in CY 2023. If the topline results at the completion of the primary efficacy phase are favourable, we intend to file for marketing approval for OPT-302 for the treatment of wet AMD in the United States, European Union and other territories.

Further validating Opthea’s scientific approach with OPT-302, we reported data in June 2020 from the company’s Phase 2a trial of OPT-302 in a second ophthalmic disease indication, diabetic macular edema (DME). DME is a complication of diabetic retinopathy, a condition caused by chronically elevated glucose levels in diabetics that damages the retina. DME can cause blurred vision, severe vision loss and blindness.

In our Phase 1b/2a clinical trial of OPT-302 in combination with aflibercept in patients with treatment-refractory DME, we observed evidence of improved clinical outcomes following OPT-302 combination therapy. This data builds on the company’s successful Phase 1/2a and Phase 2b clinical trials in wet AMD and our conviction that OPT-302 has the potential to deliver therapeutic benefit in DME patients. Of relevance to our Phase 3 COAST trial, our DME trial results informed the safety profile of OPT-302 in combination with aflibercept. Opthea now has extensive clinical dosing experience with OPT-302 in approximately 400 patients, across three international clinical studies in two disease indications and in combination with the two leading standard of care VEGF-A inhibitors ranibizumab or aflibercept.

In the financial sphere, in October 2020 Opthea raised net proceeds of $164.9 million equity capital in a US initial public offering (IPO) and NASDAQ listing supported by Australian, US and UK based institutional investors. Opthea is now dual listed on the ASX and NASDAQ where its American Depositary Shares (ADS) are listed at a ratio of 8 ordinary shares to one ADS. The proceeds of the financing will primarily be used to progress OPT-302 into the Phase 3 clinical program and to develop a co formulation of OPT-302 with a biosimilar anti-VEGF-A therapy. We believe that a co-formulated OPT-302 and VEGF-A inhibitor product has the potential to be a market-leading treatment for wet AMD that offers the convenience of a single-injection to achieve broader inhibition of the VEGF signalling pathway, including VEGF-A, VEGF-C and VEGF-D.

 


 

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3

 

To facilitate the progression of Opthea’s clinical development program, Opthea has entered into research and development contracts with various third parties, including global contract manufacturing and contract research organisations to provide services for the manufacture of OPT-302 and conduct of clinical trials. These activities and forecast expenditure in note 14 (page 15) are consistent with planned use-of-proceeds from the October 2020 IPO and NASDAQ listing, as disclosed at that time. We continue to evaluate our capital requirements based on assumed activities and forecast expenditures.

I N T E L L E C T U A L   P R O P E R T Y

Opthea owns a patent family covering the OPT-302 molecule, and uses thereof, extending out to February 2034. This patent has been filed in 19 jurisdictions and has already granted in the United States, Europe (validated in 38 countries), Japan, Canada, Israel, Australia, New Zealand, Malaysia, Indonesia, Singapore, Mexico, South Africa, Colombia and Russia. The patent application has been accepted for grant in South Korea, and is currently pending in China, Brazil, India and the Philippines.

The United States patent, which granted in August 2017, includes broad claims to the OPT-302 molecule, and analogues thereof, and their use to treat disorders involving neovascularisation, including eye diseases such as wet AMD and DME. In the United States, Opthea has another granted patent relating to soluble VEGFR-3 molecules which includes composition of matter claims to soluble VEGFR-3 molecules (such as OPT -302) and extends out to November 2026.

I M P A C T   O F   C O V I D - 1 9

We are closely monitoring how the COVID-19 situation is affecting our employees, business, preclinical studies and clinical trials. In response to the COVID-19 pandemic, all of our employees have transitioned to working remotely and travel has been restricted. Although operations to date have not been materially affected by the COVID-19 pandemic, at this time, there is significant uncertainty relating to the trajectory of the pandemic. The impact of related responses and disruptions caused by the COVID-19 pandemic may result in difficulties or delays in initiating, enrolling, conducting or completing future clinical trials and the Company incurring unforeseen costs as a result of disruptions in clinical supply or clinical trial delays.

The impact of COVID-19 on our future results will largely depend on future developments, which are highly uncertain and cannot be predicted with confidence, such as the ultimate geographic spread of the disease, the duration of the pandemic, travel restrictions and social distancing in Australia, the United States and other countries, business closures or business disruptions,

Management will continue to monitor potential impacts of the COVID-19 situation on Opthea and mitigate risks to clinical trial patients, employees and development timelines.

F U T U R E   D E V E L O P M E N T S

Opthea continues to advance the clinical development of OPT-302 to key commercial milestones through the completion of manufacturing, regulatory engagement and planning for Phase 3 pivotal trials in wet AMD.

The key objectives of the Company over the next 12 months are to:

wet AMD

 

/

Complete the manufacture of cGMP, clinical grade OPT-302 for Phase 3 clinical trials;

 

/

Open Phase 3 ShORe and COAST clinical trial sites globally (USA, Europe, Asia Pacific);

 

/

Commence patient recruitment into the company’s Phase 3 clinical trials for wet AMD;

 

/

Progress development of a co-formulation of OPT-302 with a biosimilar VEGF-A inhibitor; and

 

/

Publish outcomes of the Phase 2b wet AMD trial in a peer reviewed journal.

DME

 

/

Publish outcomes of the Phase 1b and Phase 2a DME trials in peer reviewed journals.

Corporate

 

/

Broaden Opthea’s geographical reach by establishing US-based operations;

 

/

Ensure the global investment and pharmaceutical/biotechnology community is aware of the commercial potential inherent in OPT-302; and

 

/

Prepare for various and all opportunities to advance further development of OPT-302 through investment out-reach and engagement with pharmaceutical/biotechnology companies in the sector.

On behalf of the Directors

 

LOGO

Jeremy Levin

Chairman

Melbourne,

22 February 2021

 


    4

 

A U D I T O R ’ S   I N D E P E N D E N C E

D E C L A R A T I O N

 

LOGO

Deloitte Touche Tohmatsu ABN 74 490 121 060 Tower 2, Brookfield Place 123 St Georges Terrace Perth WA 6000 GPO Box A46 Perth WA 6837 Australia Tel: +61 8 9365 7000 Fax: +61 8 9365 7001 www.deloitte.com.auThe Board of Directors Opthea Limited Suite 403, Level 4 650 Chapel Street South Yarra VIC 3141 22 February 2021 Dear Board Members Opthea Limited In accordance with section 307C of the Corporations Act 2001, I am pleased to provide the following declaration of independence to the directors of Opthea Limited. As lead audit partner for the review of the financial statements of Opthea Limited for the half year ended 31 December 2020, I declare that to the best of my knowledge and belief, there have been no contraventions of: (i) the auditor independence requirements of the Corporations Act 2001 in relation to the review; and (ii) any applicable code of professional conduct in relation to the review. Yours sincerelyDELOITTE TOUCHE TOHMATSUVincent Snijders Partner Chartered Accountant Liability limited by a scheme approved under Professional Standards Legislation Member of Deloitte Asia Pacific Limited and the Deloitte organisation.


 

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5

 

CONDENSED CONSOLIDATED STATEMENT OF PROFIT OR LOSS AND OTHER COMPREHENSIVE INCOME FOR THE HALF-YEAR ENDED 31 DECEMBER 2020

 

                    31 December  
            2020      2019  
      Note      $      $  

Revenue

              314,294        273,115  

Other income

              37,500         

Research and development expenses

              (18,807,475      (8,340,640 )   

Administrative expenses

              (5,275,670      (2,416,266 )  

Share-based payments expense

              (2,218,242      (880,365

Patent and intellectual property expenses

              (100,356      (203,982

Occupancy expenses

              (12,247      (10,442

Net foreign exchange (loss)/gain

     5        (12,442,849      113,370  

Loss before income tax

              (38,505,045      (11,465,210

Income tax benefit

     6        3,522,832        3,845,192  

Loss for period

              (34,982,213      (7,620,018

    

                          

Other comprehensive income

                          

Items that will not be subsequently reclassified to profit or loss:

                          

Fair value gains on investments in financial assets

              649,804        83,696  

Other comprehensive income for the period

              649,804        83,696  

Total comprehensive loss for the period

              (34,332,409      (7,536,322

Earnings per share for loss attributable for the ordinary equity holders of the parent:

                          

Basic and diluted loss per share (cents)

              (11.75      (3.02

Notes to the financial statements are included on pages 9 to 15.


    6

 

CONDENSED CONSOLIDATED STATEMENT OF FINANCIAL POSITION AS AT 31 DECEMBER 2020

 

     

Note

    

31 December
2020

$

    

30 June
2020

$

 

Current Assets

                          

Cash and cash equivalents

     7        202,544,985        62,020,382  

Current tax receivable

              3,522,832        8,533,123  

Receivables

              849,940        284,391  

Prepayments

     8        6,083,901        478,632  

Total current assets

              213,001,658        71,316,528  

    

                          

Non-current assets

                          

Investments in financial assets

     9               289,980  

Plant and equipment

              29,730        37,180  

Right-of-use asset

     10        182,632        243,510  

Total non-current assets

              212,362        570,670  

Total assets

              213,214,020        71,887,198  

    

                          

Current liabilities

                          

Payables

              2,523,468        5,895,034  

Lease liabilities

     11        145,043        145,043  

Other financial liabilities

     5        12,165,618        237,820  

Provisions

              682,259        640,934  

Total current liabilities

              15,457,279        6,918,831  

    

                          

Non-current liabilities

                          

Lease liabilities

     11        60,849        120,033  

Provisions

              50,676        40,197  

Total non-current liabilities

              170,709        160,230  

Total liabilities

              15,627,988        7,079,061  

Net assets

              197,586,107        64,808,137  

    

                          

Equity

                          

Contributed equity: ordinary shares

     12        310,725,758        162,102,553  

Contributed equity: pre-funded warrants

     12        16,268,932         

Accumulated losses

              (137,571,554      (102,589,341 )   

Reserves

     13        8,162,971        5,294,925  

Total equity

              197,586,107        64,808,137  

Notes to the financial statements are included on pages 9 to 15.


 

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CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN EQUITY FOR THE HALF-YEAR ENDED 31 DECEMBER 2020

 

     

Contributed
equity

$

    

Share-based
payments
reserve

$

    

Fair value of
investments
reserve

$

    

Accumulated
losses

$

     Total equity
$
 

As at 1 July 2020

     162,102,553          4,498,830          796,095          (102,589,341)          64,808,137     

Fair value gains on investments in financial assets

     –          –          649,804          –           649,804     

Loss for the period

     –          –          –          (34,982,213)          (34,982,213)    

Total comprehensive income and expense for the period

     –          –          649,804          (34,982,213)          (34,332,409)    

Recognition of share based payment

     –          2,218,242          –          –           2,218,242     

Issue of ordinary shares

     148,623,205          –          –          –           148,623,205     

Issue of pre-funded warrants

     16,268,932          –          –          –           16,268,932     

Balance as at 31 December 2020

     326,994,690          6,717,072          1,445,899          (137,571,554)          197,586,107     

    

                                             

As at 1 July 2019

     113,021,993          3,420,348          737,255          (86,060,059)          31,119,537     

Fair value gains on investments in financial assets

     –          –          83,696          –           83,696     

Loss for the period

     –          –          –          (7,620,018)          (7,620,018)    

Total comprehensive income and expense for the period

     –          –          83,696          (7,620,018)          (7,536,322)    

Recognition of share based payment

     –          880,365          –          –           880,365     

Issue of ordinary shares and exercise of LTIP options

     49,142,444          –          –          –           49,142,444     

Balance as at 31 December 2019

     162,164,437          4,300,713          820,951          (93,680,077)          73,606,024     

Notes to the financial statements are included on pages 9 to 15.


    8

 

CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS FOR THE HALF-YEAR ENDED 31 DECEMBER 2020

 

     31 December  
     

2020

$

    

2019

$

 
Cash flows from operating activities                  
Interest received      237,547        223,521  
Royalty and licence income received      49,320        25,412  
Grant income received      37,500         
Payment of lease interest      (3,840       
Payments to suppliers, employees and for research and development and intellectual property costs (inclusive of GST)      (33,584,098      (10,975,551 )   
Research and development tax incentive scheme credit received      8,533,123        14,636,973  
Net cash flows (used in)/provided by operating activities      (24,730,448      3,910,355  
                      
Cash flows from investing activities                  
Cash received on disposal of financial asset      939,784        482,978  
Purchase of plant and equipment      (2,635      (4,159
Net cash flows provided by investing activities      937,149        478,819  
                      
Cash flows from financing activities                  
Payment of lease liabilities      (59,184      (66,664
Net proceeds on issue of ordinary shares      148,623,205        49,142,444  
Net proceeds on issue of pre-funded warrants      16,268,932         
Net cash flows provided by financing activities      164,832,953        49,075,780  
                      
Net increase in cash and cash equivalents      141,039,654        53,464,954  
Effect of foreign exchange rate changes      (515,051      87,778  
Cash and cash equivalents at beginning of the period      62,020,382        21,534,919  
Cash and cash equivalents at end of the period      202,544,985        75,087,651  

Notes to the financial statements are included on pages 9 to 15.


 

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NOTES TO THE CONDENSED CONSOLIDATED

FINANCIAL STATEMENTS FOR THE

HALF-YEAR ENDED 31 DECEMBER 2020

 

1.   CORPORATE INFORMATION

The consolidated financial report of Opthea Limited (the Group) for the half-year ended 31 December 2020 was authorised for issue in accordance with a resolution of the directors on 22 February 2021.

Opthea Limited (the parent) is a company limited by shares incorporated in Australia whose ordinary shares are publicly traded on the Australian Securities Exchange (ASX) and whose ADSs are listed on the NASDAQ.

2.   ADOPTION OF NEW AND REVISED AUSTRALIAN ACCOUNTING STANDARDS

New and amended Accounting Standards that are effective for the current period

The Group has adopted all of the new and revised Standards and Interpretations issued by the Australian Accounting Standards Board (the AASB) that are relevant to their operations and effective for the current half-year.

New and revised Standards and amendments thereof and Interpretations effective for the current half-year that are relevant to the Group include:

 

/

AASB 2018-6 Amendments to Australian Accounting Standards – Definition of a Business

 

/

AASB 2018-7 Amendments to Australian Accounting Standards – Definition of Material

 

/

AASB 2019-1 Amendments to Australian Accounting Standards – References to the Conceptual Framework

 

/

AASB 2019-5 Amendments to Australian Accounting Standards – Disclosure of the Effect of New IFRS Standards Not Yet Issued in Australia

In the current half-year, the Group has applied the above amendments to Australian Accounting Standards issued by the AASB that are effective for the Group’s annual reporting period that began on 1 July 2020. Their adoption has had no material impact on the disclosures and/or amounts reported in these financial statements.

3.   SIGNIFICANT ACCOUNTING POLICIES

Basis of preparation

These condensed consolidated financial statements have been prepared on the basis of historical cost, except for the revaluation of certain non-current assets and financial instruments. Cost is based on the fair values of the consideration given in exchange for assets. All amounts are presented in Australian dollars, unless otherwise noted.

The accounting policies and methods of computation adopted in the preparation of the half-year financial report are consistent with those adopted and disclosed in the company’s 2020 annual financial report for the financial year ended 30 June 2020. The accounting policies are consistent with Australian Accounting Standards and with International Financial Reporting Standards.

Research and development costs

Research costs are expensed as incurred. An intangible asset arising from the development expenditure on an internal project will only be recognised when the Group can demonstrate the technical feasibility of completing the intangible asset so that it will be available for use or sale, its intention to complete and its ability to use or sell the asset, how the asset will generate future economic benefits, the availability of resources to complete the development and the ability to measure reliably the expenditure attributable to the intangible asset during its development.

As of 31 December 2020, the Group is in the research phase and has not capitalised any development costs to date.

Income tax

Current tax

Current tax assets and liabilities for the current and prior periods are measured at the amount expected to be recovered from or paid to the taxation authorities based on the current period’s taxable income. The tax rates and tax laws used to compute the amount are those that are enacted or substantively enacted by the reporting date.

Research and development tax incentive

The Research and Development (R&D) Tax Incentive Scheme is an Australian Federal Government program under which eligible companies with annual aggregated revenue of less than $20 million can receive cash amounts equal to 43.5% of eligible research and development expenditures from the Australian Taxation Office (ATO). The R&D Tax Incentive Scheme incentive relates to eligible expenditure incurred in Australia and, under certain circumstances, overseas on the development of the Group’s lead candidate, OPT -302. The R&D tax incentive is applied annually to eligible expenditure incurred during the Group’s financial year following annual application to AusIndustry, an Australian governmental agency, and subsequent filing of its Income Tax Return with the ATO after the financial year end.

 


    10

 

NOTES TO THE CONSOLIDATED FINANCIAL

STATEMENTS FOR THE HALF-YEAR ENDED

31 DECEMBER 2020 (CONT.)

 

The Group estimates the amount of R&D tax incentive after the completion of the financial year based on eligible Australia and overseas expenditures incurred during that year. The Group has presented incentives in respect of the R&D Tax Incentive Scheme within income tax benefit in the Statement of Profit or Loss and Other Comprehensive Income by analogising with AASB 112 “Income Taxes”.

Leases

The Group assesses at contract inception whether a contract is, or contains, a lease. A contract is, or contains, a lease if the contract conveys the right to control the use of an identified asset for a period of time in exchange for consideration.

The Group applies a single recognition and measurement approach for all leases, except for short-term leases and leases of low-value assets. The Group recognises lease liabilities to make lease payments and right-of-use assets representing the right to use the underlying assets.

Right-of-use assets

Right-of-use assets are recognised at the commencement date of the lease (that is the date the underlying asset is available for use). Right-of-use assets are measured at cost, less any accumulated depreciation and any impairment losses, and adjusted for any remeasurement of lease liabilities. The cost of right-of-use assets includes the amount of lease liabilities recognised, initial direct costs incurred, and lease payments made at or before the commencement date less any lease incentives received. Right-of-use assets are depreciated on a straight-line basis over the shorter of the lease terms and the estimated useful lives of the assets.

Lease liabilities

Lease liabilities are recognised at the commencement date of the lease at the present value of lease payments to be made over the lease term. The lease payments include fixed payments (including in-substance fixed payments) less any lease incentives receivable.

In calculating the present value of lease payments, the Group uses its incremental borrowing rate at the lease commencement date because the interest rate implicit in the lease is not readily determinable. The incremental borrowing rate is determined using market yields on bonds with similar terms to maturity. After the commencement date, the amount of lease liabilities is increased to reflect the accretion of interest and reduced for the lease payments made. In addition, the carrying amount of lease liabilities is remeasured if there is a modification, a change in the lease term, a change in lease payments (e.g. a change to future lease payments resulting from a change in an index or rate).

Leases of low-value assets

For short-term leases (lease term of 12 months or less) and leases of low-value assets (such as photo copiers and telephones), the Group has opted to recognise a lease expense on a straight-line basis as permitted by AASB 16. This expense is presented within “administrative expenses” in the Consolidated Statement of Profit or Loss and Other Comprehensive Income.

Contributed equity – pre-funded warrants

Pre-funded warrants are classified as equity. Incremental costs directly attributable to the issue of new warrants are shown in equity as a deduction, net of tax, from the proceeds.

4.   OPERATING SEGMENTS

The Group operates in one industry and one geographical area, those being the biotechnology and healthcare industry and Australia, respectively.

The Group is focused primarily on developing a novel therapy for the treatment of highly prevalent and progressive retinal diseases.

The chief executive officer regularly reviews entity wide information that is compliant with Australian Accounting Standards. There is only one segment for segment reporting purposes, and the information reviewed by the chief executive officer for the purpose of resources allocation and performance assessment is the same as the information presented in the consolidated financial statements.

The Group’s only revenue stream in the current half-year is royalty income generated from licenses granted in respect of the Group’s intellectual property that are unrelated to the Group’s core business and the development of OPT-302 and that are not under development. These licenses are primarily used by third-party licensees for research purposes. All of the royalty income for the half-year ended 31 December 2020 of $41,465 (31 December 2019: $4,390) was generated from customers based outside Australia. The Group does not have any major customers. All property, plant and equipment is located in Australia.

 


 

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5 .   NET FOREIGN EXCHANGE (LOSS)/GAIN

 

                                           
     

31 December

2020

$

   

31 December
2019

$

 

Net foreign exchange (losses)/gains

     (277,231     87,778  

Financial (liabilities)/assets at fair value through profit or loss

     (12,165,618     25,592  
       (12,442,849     113,370   

Shortly after the Company’s US IPO where the Company raised USD 128 million, the Company entered into an Australian dollar denominated term deposit worth USD 100 million (AUD 141.9 million), maturing on 3 February 2021. The Company simultaneously entered into a foreign currency exchange contract under which the term deposit will be converted back to US dollars at effectively the same foreign exchange rate as when the term deposit was entered into. The financial liability represents the marked to market value of this foreign currency exchange contract held at 31 December 2020. Subsequent to 31 December 2020, upon maturity and settlement of the term deposit and foreign exchange contract on 3 February 2021, the Australian dollar denominated term deposit was converted back to US dollars for a value of USD 100 million plus interest earned of AUD 116 thousand.

6.   INCOME TAX

A reconciliation between tax benefit and the product of accounting loss before income tax multiplied by the Group’s applicable income tax rate is as follows:

 

                                           
     

31 December

2020

$

   

31 December

2019

$

 

Accounting loss before tax

     (38,505,045     (11,465,210

At the parent entity’s statutory income tax rate of 27.5%

     10,588,887       3,152,933  

Research and development tax incentive on eligible expenses

     3,522,832       3,845,192  

Non-deductible R&D expenditure

     (2,227,078     (2,579,092

Other non-deductible expenses – share based payment expense

     (610,017     (242,100

Amount of temporary differences and carried forward tax losses not recognised

     (7,751,792     (331,741

Income tax benefit reported in the Statement of Profit or Loss and Other Comprehensive Income

     3,522,832       3,845,192  

7.   CASH AND CASH EQUIVALENTS

 

                                           
     

31 December

2020

$

   

30 June

2020

$

 

For the purpose of the half-year statement of cash flows, cash and cash equivalents are comprised of the following:

                

Cash at bank and in hand

     10,603,769       3,020,382  

Short term deposits

     191,941,216       59,000,000  
       202,544,985        62,020,382   

Cash at bank earns interest at floating rates based on daily bank deposit rates.

Short term-deposits are with major Australian banks and are made for varying periods of between 90 days and 96 days, depending on the immediate cash requirements of the Group, and earn interest at a fixed rate for the respective short-term deposit periods. At period end, the average rate was 0.36% (2019 half-year: 1.59%).


    12

 

NOTES TO THE CONSOLIDATED FINANCIAL

STATEMENTS FOR THE HALF-YEAR ENDED

31 DECEMBER 2020 (CONT.)

8.   PREPAYMENTS

 

     

31 December
2020

$

    

30 June 

2020 

 
                   

Prepayments in respect of insurance premiums paid in advance

     6,074,496        466,083   

Other administrative expense prepayments

     9,405        12,549   
       6,083,901                478,632   

9.   NON-CURRENT ASSETS – INVESTMENTS IN FINANCIAL ASSETS

 

Listed investments   

Ownership

interest

%

    

Fair value at

period end 1

$

    

Disposals

$

    

Fair value

gain/(loss)

recognised

in OCI

$

    

Opening fair 

value 

 

31 December 2020

                                            

Non-current investments

                                            

Antisense Therapeutics Ltd

            –          –           –           –     

Optiscan Imaging Ltd

            –          (939,784)          649,804           289,980     

Total listed investments

              –          (939,784)          649,804           289,980     

30 June 2020

                                            

Antisense Therapeutics Ltd

            –          (482,978)          249,399           233,579     

Optiscan Imaging Ltd

       1.73%        289,980                              –           (190,559)          480,539     

Total listed investments

                      289,980          (482,978)                     58,840                   714,118     

 

1.

The fair value represents the share (bid) price at period end, and does not include any capital gains tax or selling costs that may be applicable on the disposal of these investments.

Non-current investments in listed shares (which are not associates) are designated and accounted for as investments in financial assets pursuant to AASB 9.


 

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10.   RIGHT-OF-USE ASSET

 

     

Lease of  

office  

premises  

$  

 

Right of Use Asset Cost

        

At 1 July 2020

     365,264    

Additions

     –    

At 31 December 2020

     365,264    

Accumulated depreciation

        

At 1 July 2020

     (121,754)   

Charge for the half-year

     (60,878)   

At 31 December 2020

     (182,632)   

Net carrying amount

        

At 31 December 2020

     182,632    

At 30 June 2020

     243,510    

The Group leases its main office accommodation for employees. The term of the lease is three years and is the renewal of a lease for the same premises that expired on 15 July 2019. The lease does not include the option to extend the term of the lease on expiry.

The maturity analysis of lease liabilities is presented in note 11.

 

     

31 December
2020

$

   

31 December  

2019  

$  

 

Amounts recognised in profit or loss

                

Depreciation expense on right-of-use asset

     60,878       69,197    

Lease finance costs

     3,840       3,556    

Expense relating to leases of low value assets

     4,835       4,835    
       69,553       77,588    

 

11.   LEASE LIABILITIES

 

 

     

31 December
2020

$

   

30 June  

2020  

$  

 

Carrying amount at 1 July

     265,076       –    

New Lease

           365,264    

Payments

     (59,184     (100,189)   

Carrying amount at 31 December/30 June

     205,892       265,076    

Maturity analysis:

                

Year 1

     89,699       152,723    

Year 2

     123,873       127,713    
       213,572       280,436    

Less: unearned interest

     (7,680     (15,360)   
       205,892       265,076    

Analysed into:

                

Current portion

     145,043       145,043    

Non-current portion

     60,849       120,033    
       205,892       265,076    


    14

 

NOTES TO THE CONSOLIDATED FINANCIAL

STATEMENTS FOR THE HALF-YEAR ENDED

31 DECEMBER 2020 (CONT.)

 

12.

CONTRIBUTED EQUITY

 

     31 December
2020
   

30 June

2020

 
      $     $  

(a) Ordinary shares

                

Issued and fully paid at 31 December/30 June

     310,725,758       162,102,553  

Movement in ordinary shares:

                

Opening balance

     162,102,553       113,021,993  

Issue of shares in a private placement

           48,660,560  

Issue of shares on exercise of options granted under the LTIP

           420,000  

Issue of shares in a US Initial Public Offering (US IPO) and NASDAQ listing

     162,892,597        

Cost of issue of shares for US IPO

     (14,269,392      
       310,725,758       162,102,553  

Ordinary shares on issue:

     No:       No:  

Opening balance

     269,157,769       249,414,839  

Issue of shares in a placement

           18,867,930  

Issue of shares on exercise of options granted under the LTIP

           875,000  

Issue of shares in a US IPO and NASDAQ listing

     68,506,400        
       337,664,169       269,157,769  

Issued capital of ordinary shares at 31 December 2020 amounted to $310,725,758 (337,664,169 fully paid ordinary shares) net of share issue costs and tax. During the half-year, the Company issued 68,506,400 ordinary shares for $148,623,205 net of issue costs in respect of a US initial public offering of American Depositary Shares (ADSs) on the NASDAQ.

 

     31 December
2020
    30 June
2020
 
      $     $  

(b) Pre-funded warrants

                

Movement in pre-funded warrants:

                

Opening balance

            

Issue of pre-funded warrants in a US IPO

     17,818,059        

Cost of issue of pre-funded warrants

     (1,549,127        
       16,268,932        

Pre-funded warrants on issue:

     No:       No:  

Opening balance

            

Issue of pre-funded warrants in a US IPO

     7,493,600        
       7,493,600        

The Company issued 7,493,600 pre-funded warrants for $16,268,932 net of issue costs in respect of a US initial public offering.

The pre-funded warrants are unquoted, have no voting or dividend rights attached and are exercisable to ADSs at an exercise price of US$0.00001 per pre-funded warrant on a one for one basis with no expiry date.


 

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13.    RESERVES

 

     31 December      30 June    
     2020      2020    
      $      $    

Fair value of investments reserve 1

     1,445,899        796,095    

Share-based payments reserve 2

     6,717,072        4,498,830    

Total reserves

     8,162,971        5,294,925    

1. Movement in fair value of investments reserve:

                  

Opening balance

     796,095        737,255    

Fair value gains on investments in financial assets

     649,804        58,840    

Closing balance

     1,445,899        796,095    

    

                  

2. Movement in share-based payments reserve:

                 

Opening balance

     4,498,830        3,420,349    

Share-based payments expense

     2,218,242        1,078,481    

Closing balance

     6,717,072        4,498,830    

14.    COMMITMENTS

The Company has entered into research and development contracts with various third parties in respect of the manufacture of clinical grade OPT-302 and services for the Phase 3 wet AMD clinical trials. Expenditure commitments relating to these and intellectual property license agreements are payable as follows:

 

     31 December      30 June    
     2020      2020    
      $      $    

    

                 

Within one year

     18,573,692        11,145,736    

After one year but not more than five years

     1,066,071        444,143    

After more than five years

     97,298        109,061    
       19,737,061        11,698,940    

15.    EVENTS SUBSEQUENT TO REPORTING DATE

No matters or circumstances have arisen since the end of the reporting period, not otherwise disclosed in this report, which significantly affected, or may significantly affect, the operations of the Group, the results of those operations, or the state of affairs of the Group in future financial years.


            

  

16

  

 

 

D I R E C T O R S’   D E C L A R A T I O N

The Directors declare that:

 

  a.

in the Directors’ opinion, there are reasonable grounds to believe that the company will be able to pay its debts as and when they become due and payable; and

 

  b.

in the Directors’ opinion, the attached financial statements and notes thereto are in accordance with the Corporations Act 2001, including compliance with accounting standards and giving a true and fair view of the financial position and performance of the consolidated entity.

Signed in accordance with a resolution of the Directors made pursuant to s.303(5) of the Corporations Act 2001.

On behalf of the Directors

 

LOGO

Jeremy Levin

Chairman

Melbourne,

22 February 2021


 

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I N D E P E N D E NT  A U D I T O R ’ S

R E V I E W  R E P O R T

 

 

LOGO

    Deloitte Touche Tohmatsu
    ABN 74 490 121 060
   

Tower 2, Brookfield Place

123 St Georges Terrace

    Perth WA 6000
    GPO Box A46
    Perth WA 6837 Australia
    Tel: +61 8 9365 7000
   

Fax: +61 8 9365 7001

www.deloitte.com.au

Independent Auditor’s Review Report to the members of Opthea Limited

Conclusion

We have reviewed the half-year financial report of Opthea Limited (the “Company”) and its subsidiary (the “Group”), which comprises the condensed consolidated statement of financial position as at 31 December 2020, and the condensed consolidated income statement, the condensed consolidated statement of comprehensive income, the condensed consolidated statement of cash flows and the condensed consolidated statement of changes in equity for the half-year ended on that date, notes comprising a summary of significant accounting policies and other explanatory information, and the directors’ declaration as set out on pages 5 to 16.

Based on our review, which is not an audit, we have not become aware of any matter that makes us believe that the half-year financial report of Opthea Limited is not in accordance with the Corporations Act 2001, including:

 

  (a)

giving a true and fair view of the Group’s financial position as at 31 December 2020 and of its performance for the half-year ended on that date; and

 

 

  (b)

complying with Accounting Standard AASB 134 Interim Financial Reporting and the Corporations Regulations 2001.

 

Basis for Conclusion

We conducted our review in accordance with ASRE 2410 Review of a Financial Report Performed by the Independent Auditor of the Entity. Our responsibilities are further described in the Auditor’s Responsibilities for the Review of the Half-year Financial Report section of our report. We are independent of Opthea Limited in accordance with the ethical requirements of the Accounting Professional and Ethical Standards Board’s APES 110 Code of Ethics for Professional Accountants (including Independence Standards) (the Code) that are relevant to our audit of the annual financial report in Australia. We have also fulfilled our other ethical responsibilities in accordance with the Code.

We confirm that the independence declaration required by the Corporations Act 2001, which has been given to the directors of the Company, would be in the same terms if given to the directors as at the time of this auditor’s review report.

Directors’ Responsibilities for the Half-year Financial Report

The directors of the Company are responsible for the preparation of the half-year financial report that gives a true and fair view in accordance with Australian Accounting Standards and the Corporations Act 2001 and for such internal control as the directors determine is necessary to enable the preparation of the half-year financial report that gives a true and fair view and is free from material misstatement, whether due to fraud or error.

Liability limited by a scheme approved under Professional Standards Legislation

Member of Deloitte Asia Pacific Limited and the Deloitte organisation.

 


            

  

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INDEPENDENT  AUDITOR’S  REVIEW  REPORT  (CONT.)

 

 

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Auditor’s Responsibilities for the Review of the Half-year Financial Report

Our responsibility is to express a conclusion on the half-year financial report based on our review. ASRE 2410 requires us to conclude whether we have become aware of any matter that makes us believe that the half-year financial report is not in accordance with the Corporations Act 2001 including giving a true and fair view of the Group’s financial position as at 31 December 2020 and its performance for the half-year ended on that date, and complying with Accounting Standard AASB 134 Interim Financial Reporting and the Corporations Regulations 2001.

A review of a half-year financial report consists of making enquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other review procedures. A review is substantially less in scope than an audit conducted in accordance with Australian Auditing Standards and consequently does not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly, we do not express an audit opinion.

 

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DELOITTE TOUCHE TOHMATSU

 

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Vincent Snijders

Partner

Chartered Accountants

Perth, 22 February 2021


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