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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands
3 Months Ended 6 Months Ended
Aug. 16, 2020
USD ($)
Jun. 30, 2020
USD ($)
Targets
Jun. 30, 2019
USD ($)
Jun. 30, 2020
USD ($)
Targets
Jun. 30, 2019
USD ($)
Dec. 31, 2019
USD ($)
Commitments and Contingencies Disclosure [Line Items]            
Research and development expense   $ 21,666 $ 16,397 $ 43,363 $ 29,643  
Accrued expenses   8,565   8,565   $ 3,746
DE Shaw Research [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Accrued expenses   1,596   $ 1,596   372
DE Shaw Research [Member] | License Agreement Terms [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Research and development arrangement, term of contract       3 years    
Research and development arrangement, annual fee   1,000   $ 1,000    
Milestone payment Due   0   0   0
Research and development expense   974 250 $ 1,224 500  
DE Shaw Research [Member] | License Agreement Terms [Member] | Forecast [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Research and development arrangement, annual fee $ 7,900          
Research and development arrangement, expiration date Aug. 16, 2025          
DE Shaw Research [Member] | License Agreement Terms [Member] | Maximum [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Agreement renewal period       1 year    
Potential development milestone payments       $ 7,300    
Other Third Parties [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Research and development expense   236 $ 380 1,430 $ 626  
Other Third Parties [Member] | License Agreement Terms [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Milestone payment Due   $ 0   0   $ 0
Other Third Parties [Member] | License Agreement Terms [Member] | Maximum [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Potential development milestone payments       $ 7,000    
Number of milestone targets | Targets   4   4    
Other Third Parties [Member] | License Agreement Terms [Member] | Minimum [Member]            
Commitments and Contingencies Disclosure [Line Items]            
Potential development milestone payments       $ 4,000