Commitments and Contingencies - Additional Information (Detail)		12 Months Ended
	Jun. 15, 2020 USD ($)	Dec. 31, 2021 USD ($) Target shares	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($) shares
Commitments and Contingencies Disclosure [Line Items]
Accrued expenses		$ 13,953,000	$ 5,760,000
DE Shaw Research [Member]
Commitments and Contingencies Disclosure [Line Items]
Research and development expense		9,500,000	6,400,000	$ 1,500,000
Prepaid expense		$ 4,400,000
Accrued expenses			1,500,000
DE Shaw Research [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Outstanding convertible preferred stock converted into common shares | shares		3,281,253
Research and development arrangement, annual fee	$ 9,900,000			1,000,000.0
Research and development arrangement, term of contract		3 years
Research and development arrangement, expiration date	Aug. 16, 2025
Milestone payment Due		$ 7,300,000
Maximum additional amount received upon milestone achievement		6,300,000
DE Shaw Research [Member] | Lease Agreement
Commitments and Contingencies Disclosure [Line Items]
Milestone payment Due		0	1,500,000
Other Third Parties [Member]
Commitments and Contingencies Disclosure [Line Items]
Research and development expense		5,400,000	2,700,000	$ 3,500,000
Other Third Parties [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Milestone payment Due		$ 500,000	$ 0
Number of milestone targets | Target		4
Series A Preferred Stock [Member] | DE Shaw Research [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Shares held | shares				9,999,999
Series C Preferred Stock [Member] | DE Shaw Research [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Shares held | shares				1,557,875
Maximum [Member] | DE Shaw Research [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Agreement renewal period		1 year
Potential development milestone payments		$ 7,300,000
Maximum [Member] | Other Third Parties [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Potential development milestone payments		7,000,000.0
Minimum [Member] | Other Third Parties [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Potential development milestone payments		$ 4,000,000.0