Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of Effective Income Tax Rate

A reconciliation from U.S. statutory rate of 21% to the effective rate is as follows:

	Year Ended December 31,
	2021			2020			2019
Federal Statutory rate		21.0	%		21.0	%		21.0	%
State tax expense		7.1	%		0.0	%		7.0	%
Stock-based compensation		349.5	%		0.0	%		0.0	%
Change in fair value of assumed common stock warrant liabilities		103.1	%		(7.3	%)		0.0	%
Research and development tax credit		41.5	%		0.2	%		4.5	%
Permanent tax items		(7.1	%)		(0.2	%)		(2.2	%)
State rate differential - change in apportionment		4.4	%		(0.1	%)		0.0	%
Prior year deferred true-up		2.5	%		0.1	%		0.0	%
Change in fair value of Series F tranche liabilities		0.0	%		(12.5	%)		0.0	%
Sec. 162(m) wage limitation		(113.9	%)		(0.1	%)		0.0	%
Change to valuation allowance		(408.1	%)		(1.1	%)		(30.4	%)
Effective tax rate		0.0	%		0.0	%		0.0	%

Components of Net Deferred Tax Assets

Significant components of the Company’s net deferred tax assets as of December 31, 2021 and 2020, are as follows (amounts in thousands):

	Year Ended December 31,
	2021			2020
Deferred tax assets:
Net operating losses	$	257,426		$	88,392
Tax credits		35,149			16,314
Accruals and stock-based compensation		10,479			3,313
Lease liability		20,234			2,621
Intangibles		685			1,413
Gross deferred tax assets		323,973			112,053
Valuation allowance		(293,211	)		(105,781	)
Total deferred tax assets	$	30,762		$	6,272
Deferred tax liabilities:
Right of use assets	$	(18,999	)	$	(2,463	)
Fixed assets		(11,763	)		(3,809	)
Total deferred tax liabilities		(30,762	)		(6,272	)
Total net deferred tax assets	$	—		$	—

Reconciliation of Beginning and Ending Balances of Valuation Allowance

A reconciliation of the beginning and ending balances of the valuation allowance is as follows (amounts in thousands):

	Year Ended December 31,
	2021			2020
Beginning of the year	$	(105,781	)	$	(85,677	)
Increase		(187,430	)		(20,104	)
End of the year	$	(293,211	)	$	(105,781	)

Reconciliation of Beginning and Ending Balances of Unrecognized Tax Benefits

A reconciliation of the beginning and ending balances of unrecognized tax benefits is as follows (amounts in thousands):

	Year Ended December 31,
	2021			2020
Beginning of the year	$	6,575		$	7,076
Increase—current year positions		20,633			1,553
Increase—prior year positions		5,056			193
Decrease—prior year positions		(92	)		(2,247	)
End of the year	$	32,172		$	6,575