Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating activities
Net loss	$ (123,482)	$ (83,463)	$ (45,740)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	342	51	202
Non-cash lease costs	1,124	685
Acquired in-process research and development		4,739
Stock-based compensation	23,839	13,914	5,436
Net amortization of premiums and accretion of discounts on investments	(940)
Accretion of term loan discount and issuance costs	44		421
Changes in fair value of compound derivative liability and warrants			650
Gain on assignment of lease			(126)
Loss on early debt extinguishment			621
Changes in operating assets and liabilities
Receivables due from related-party			536
Prepaid expenses and other current assets	(1,476)	(1,662)	(1,514)
Other assets	750	(9,682)	(10)
Accounts payable	4,506	3,290	(3,744)
Payable and accrued liabilities due to related party	20	1,419
Accrued expenses and other current liabilities	7,027	3,306	4,983
Other non-current liabilities	(977)	(698)	(4)
Net cash used in operating activities	(89,223)	(68,101)	(38,289)
Investing activities
Purchase of investments	(376,789)
Maturities of investments	142,800
Purchase of property and equipment	(1,427)	(666)	(31)
Acquisition of in-process research and development		(4,257)
Proceeds from assets held for sale			641
Net cash provided by (used in) investing activities	(235,416)	(4,923)	610
Financing activities
Proceeds from common stock offerings, net			368,256
Payments of offering costs			(3,848)
Proceeds from exercise of stock options under equity incentive plan	567	2,551	299
Proceeds from issuance of common stock under employee stock purchase plan	336	202
Proceeds from issuance of convertible preferred stock, net			104,680
Principal payments on finance leases	(388)	(281)
Proceeds from issuance of term loan, net	10,000
Payments of debt issuance costs	(655)
Cash paid for early debt extinguishment			(6,506)
Net cash provided by financing activities	9,860	2,472	462,881
Net increase (decrease) in cash, cash equivalents and restricted cash	(314,779)	(70,552)	425,202
Cash, cash equivalents and restricted cash at beginning of year	363,667	434,219	9,017
Cash, cash equivalents and restricted cash at end of period	48,888	363,667	434,219
Supplemental disclosure
Cash paid for interest	103	11	427
Cash paid for taxes		274	47
Supplemental disclosure of non-cash investing and financing activities
Vesting of early exercised stock options			27
Purchase of property and equipment in accounts payable and accrued expenses	2,145	237	7
Acquisition of in-process research and development in accounts payable and accrued expenses		482
Conversion of convertible preferred stock into common stock upon closing of initial public offering			175,043
Accumulated dividend on convertible preferred stock			3
Right-of-use asset acquired under operating leases	4,613	1,780
Right-of-use asset acquired under finance leases		776
Reconciliation of cash and cash equivalents and restricted cash:
Cash and cash equivalents	48,822	363,667	434,219
Restricted cash (included in other assets)	66
Total cash and cash equivalents and restricted cash	$ 48,888	$ 363,667	$ 434,219