Document Format Files
| Seq | Description | Document | Type | Size |
|---|---|---|---|---|
| 1 | 10-K | itos-10k_20201231.htm | 10-K | 3583694 |
| 2 | EX-4.3 | itos-ex43_516.htm | EX-4.3 | 40110 |
| 3 | EX-21.1 | itos-ex211_570.htm | EX-21.1 | 5247 |
| 4 | EX-23.1 | itos-ex231_515.htm | EX-23.1 | 2374 |
| 5 | EX-31.1 | itos-ex311_9.htm | EX-31.1 | 18853 |
| 6 | EX-31.2 | itos-ex312_8.htm | EX-31.2 | 18857 |
| 7 | EX-32.1 | itos-ex321_6.htm | EX-32.1 | 10490 |
| 8 | EX-32.2 | itos-ex322_7.htm | EX-32.2 | 10638 |
| 9 | GRAPHIC | gdbhyij0addj000003.jpg | GRAPHIC | 22039 |
| 10 | GRAPHIC | gdbhyij0addj000014.jpg | GRAPHIC | 30979 |
| 11 | GRAPHIC | gdbhyij0addj000020.jpg | GRAPHIC | 16384 |
| 12 | GRAPHIC | gdbhyij0addj000024.jpg | GRAPHIC | 11628 |
| 13 | GRAPHIC | gdbhyij0addj000009.jpg | GRAPHIC | 24518 |
| 14 | GRAPHIC | gdbhyij0addj000004.jpg | GRAPHIC | 24944 |
| 15 | GRAPHIC | gdbhyij0addj000016.jpg | GRAPHIC | 25735 |
| 16 | GRAPHIC | gdbhyij0addj000026.jpg | GRAPHIC | 14447 |
| 17 | GRAPHIC | gdbhyij0addj000007.jpg | GRAPHIC | 14525 |
| 18 | GRAPHIC | gdbhyij0addj000022.jpg | GRAPHIC | 13510 |
| 19 | GRAPHIC | gdbhyij0addj000012.jpg | GRAPHIC | 25419 |
| 20 | GRAPHIC | gdbhyij0addj000031.jpg | GRAPHIC | 6752 |
| 21 | GRAPHIC | gdbhyij0addj000001.jpg | GRAPHIC | 31658 |
| 22 | GRAPHIC | gdbhyij0addj000027.jpg | GRAPHIC | 11074 |
| 23 | GRAPHIC | gdbhyij0addj000002.jpg | GRAPHIC | 20884 |
| 24 | GRAPHIC | gdbhyij0addj000017.jpg | GRAPHIC | 17067 |
| 25 | GRAPHIC | gdbhyij0addj000021.jpg | GRAPHIC | 7127 |
| 26 | GRAPHIC | gdbhyij0addj000029.jpg | GRAPHIC | 15668 |
| 27 | GRAPHIC | gdbhyij0addj000025.jpg | GRAPHIC | 11182 |
| 28 | GRAPHIC | gdbhyij0addj000023.jpg | GRAPHIC | 15399 |
| 29 | GRAPHIC | gdbhyij0addj000015.jpg | GRAPHIC | 25513 |
| 30 | GRAPHIC | gdbhyij0addj000008.jpg | GRAPHIC | 26155 |
| 31 | GRAPHIC | gdbhyij0addj000013.jpg | GRAPHIC | 16211 |
| 32 | GRAPHIC | gdbhyij0addj000011.jpg | GRAPHIC | 40618 |
| 33 | GRAPHIC | gdbhyij0addj000030.jpg | GRAPHIC | 30408 |
| 34 | GRAPHIC | gdbhyij0addj000018.jpg | GRAPHIC | 19656 |
| 35 | GRAPHIC | gdbhyij0addj000028.jpg | GRAPHIC | 11005 |
| 36 | GRAPHIC | gdbhyij0addj000019.jpg | GRAPHIC | 29232 |
| 37 | GRAPHIC | gdbhyij0addj000005.jpg | GRAPHIC | 15121 |
| 38 | GRAPHIC | gdbhyij0addj000006.jpg | GRAPHIC | 17760 |
| 39 | GRAPHIC | gdbhyij0addj000010.jpg | GRAPHIC | 25146 |
| 40 | GRAPHIC | gdbhyij0addj000032.jpg | GRAPHIC | 8160 |
| Complete submission text file | 0001564590-21-015146.txt | 10519207 |
Data Files
| Seq | Description | Document | Type | Size |
|---|---|---|---|---|
| 41 | XBRL INSTANCE DOCUMENT | itos-20201231.xml | EX-101.INS | 1624766 |
| 42 | XBRL TAXONOMY EXTENSION SCHEMA | itos-20201231.xsd | EX-101.SCH | 71742 |
| 43 | XBRL TAXONOMY EXTENSION CALCULATION LINKBASE | itos-20201231_cal.xml | EX-101.CAL | 57155 |
| 44 | XBRL TAXONOMY EXTENSION DEFINITION LINKBASE | itos-20201231_def.xml | EX-101.DEF | 258009 |
| 45 | XBRL TAXONOMY EXTENSION LABEL LINKBASE | itos-20201231_lab.xml | EX-101.LAB | 520271 |
| 46 | XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE | itos-20201231_pre.xml | EX-101.PRE | 420915 |
IRS No.: 000000000 | State of Incorp.: DE | Fiscal Year End: 1231
Type: 10-K | Act: 34 | File No.: 001-39401 | Film No.: 21769091
SIC: 2836 Biological Products, (No Diagnostic Substances)
