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Stock-based compensation - Schedule of Fair Value Assumptions for Stock Options Granted (Details) - $ / shares
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Risk-free interest rate, Minimum 1.37% 0.42%
Risk-free interest rate, maximum 1.96% 0.71%
Expected Volatility, minimum 86.00% 99.00%
Expected Volatility, maximum 91.00% 100.00%
Expected dividend yield 0.00% 0.00%
Minimum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (in years) 6 years 6 years
Estimated fair value of common stock $ 36.13 $ 32.00
Maximum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Estimated fair value of common stock $ 46.56 $ 41.58