‌Exhibit 24.1

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ ERIC ANDERSEN

Eric Andersen

Director

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POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ PHILIP SAUNDERS

Philip Saunders

Director

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POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ KEVIN ROBERT

Kevin Robert

Director

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POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ J. RICHARD STAMM

J. Richard Stamm

Director

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POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ AMANDA WESTPHAL RADCLIFFE

Amanda Westphal Radcliffe

Director

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POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ STEFANIE WESTPHAL THOMPSON

Stefanie Westphal Thompson

Director

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POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned, a member of the Board of Directors of Vertex, Inc., a Delaware corporation (the "Company"), with its principal executive offices in King of Prussia, Pennsylvania, do hereby constitute, designate and appoint each of John Schwab and Bryan Rowland, each of whom are officers of the Company, as my true and lawful attorneys-in-fact, each with power of substitution and resubstitions, with full power to act without the other and on behalf of and as attorney for me, for the purpose of executing and filing with the Securities and Exchange Commission the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, and any and all amendments thereto, and to do all such other acts and execute all such other instruments which said attorney may deem necessary or desirable in connection therewith.

I have executed this Limited Power of Attorney effective as of February 12, 2024.

/s/ BRADLEY GAYTON

Bradley Gayton

Director