Income taxes - Significant Components of Consolidated Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Federal net operating loss carryforwards	$ 54,005	$ 40,469
State net operating loss carryforwards	13,705	10,643
Equity compensation	12,331	5,620
Accruals and reserves	16
Uncollected grants	993	998
Investment in subsidiaries	3,766	3,820
Research credits	1,823	1,578
Other assets	1,549	152
Deferred income		239
Interest		257
Lease liabilities	411	547
Inventory reserve	3,430
Section 174 adjustment	3,572
Total deferred tax assets	95,601	64,323
Valuation allowance	(91,842)	(59,841)
Total deferred tax assets net of valuation allowance	3,759	4,482
Deferred tax liabilities:
Intangible assets and amortization	(3,332)	(3,932)
Right-of-use asset	(400)	(536)
Other liabilities	(27)	(14)
Total deferred tax liabilities	$ (3,759)	$ (4,482)