Commitment and Contingencies - Additional Information (Details) $ in Thousands, € in Millions	1 Months Ended		12 Months Ended
	Jun. 30, 2019 USD ($)	Dec. 31, 2009	Dec. 31, 2022 USD ($)	Dec. 31, 2022 EUR (€)	Dec. 31, 2021 USD ($)
Loss Contingencies [Line Items]
Operating lease commencement	2019-06
Operating lease expiration	2025-08
Total lease payments			$ 1,686
Operating lease remaining lease terms			2 years 7 months 6 days	2 years 7 months 6 days
Operating lease weighted average discount rate, percent			5.30%	5.30%
Other long-term liabilities			$ 898		$ 5,588
Office space located in Boston
Loss Contingencies [Line Items]
Total lease payments	$ 3,200
Research and Development Tax credits
Loss Contingencies [Line Items]
Other long-term liabilities			$ 0		$ 3,000
PureTech | Royalty and Sublicense Income Agreement
Loss Contingencies [Line Items]
Royalty payment required percentage		2.00%
One S.r.l | Amended And Restated Master Agreement
Loss Contingencies [Line Items]
Percentage of royalty			2.00%
Payments to be made upon the achievement of certain milestones			$ 18,700	€ 17.5