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                            September 9, 2021

       Ilan Hadar
       Chief Executive Officer
       PAINREFORM LTD.
       4 Bruria St.
       Tel Aviv, Israel 6745442

                                                        Re: PAINREFORM LTD.
                                                            Registration
Statement on Form F-3
                                                            Filed September 3,
2021
                                                            File No. 333-259318

       Dear Mr. Hadar:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jessica
Ansart at (202) 551-4511 with any questions.




                            Sincerely,


                            Division of Corporation Finance

                            Office of Life Sciences
       cc:                                              Gary Emmanuel