<SEC-DOCUMENT>0001104659-24-089661.txt : 20240814 <SEC-HEADER>0001104659-24-089661.hdr.sgml : 20240814 <ACCEPTANCE-DATETIME>20240814162050 ACCESSION NUMBER: 0001104659-24-089661 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20240630 FILED AS OF DATE: 20240814 DATE AS OF CHANGE: 20240814 EFFECTIVENESS DATE: 20240814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: 5AM Venture Management, LLC CENTRAL INDEX KEY: 0001799883 ORGANIZATION NAME: IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-19757 FILM NUMBER: 241208292 BUSINESS ADDRESS: STREET 1: 4 EMBARCADERO CENTER, SUITE 3110 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 BUSINESS PHONE: (415) 993-8565 MAIL ADDRESS: STREET 1: 4 EMBARCADERO CENTER, SUITE 3110 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 </SEC-HEADER> <DOCUMENT> <TYPE>13F-HR <SEQUENCE>1 <FILENAME>primary_doc.xml <TEXT> <XML> <?xml version="1.0" encoding="UTF-8"?> <edgarSubmission xsi:schemaLocation="http://www.sec.gov/edgar/thirteenffiler eis_13F_Filer.xsd" xmlns="http://www.sec.gov/edgar/thirteenffiler" xmlns:ns1="http://www.sec.gov/edgar/common" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <schemaVersion>X0202</schemaVersion> <headerData> <submissionType>13F-HR</submissionType> <filerInfo> <liveTestFlag>LIVE</liveTestFlag> <flags> <confirmingCopyFlag>false</confirmingCopyFlag> <returnCopyFlag>false</returnCopyFlag> <overrideInternetFlag>false</overrideInternetFlag> </flags> <filer> <credentials> <cik>0001799883</cik> <ccc>XXXXXXXX</ccc> </credentials> </filer> <periodOfReport>06-30-2024</periodOfReport> </filerInfo> </headerData> <formData> <coverPage> <reportCalendarOrQuarter>06-30-2024</reportCalendarOrQuarter> <isAmendment>false</isAmendment> <filingManager> <name>5AM Venture Management, LLC</name> <address> <ns1:street1>4 Embarcadero Center, Suite 3110</ns1:street1> <ns1:city>San Francisco</ns1:city> <ns1:stateOrCountry>CA</ns1:stateOrCountry> <ns1:zipCode>94111</ns1:zipCode> </address> </filingManager> <reportType>13F HOLDINGS REPORT</reportType> <form13FFileNumber>028-19757</form13FFileNumber> <crdNumber>000160395</crdNumber> <secFileNumber>801-120173</secFileNumber> <provideInfoForInstruction5>N</provideInfoForInstruction5> </coverPage> <signatureBlock> <name>Paul A. Stone</name> <title>Partner and Chief Legal Officer</title> <phone>415-993-8569</phone> <signature>/s/ Paul A. Stone</signature> <city>San Francisco</city> <stateOrCountry>CA</stateOrCountry> <signatureDate>08-14-2024</signatureDate> </signatureBlock> <summaryPage> <otherIncludedManagersCount>0</otherIncludedManagersCount> <tableEntryTotal>28</tableEntryTotal> <tableValueTotal>447094225</tableValueTotal> </summaryPage> </formData> </edgarSubmission> </XML> </TEXT> </DOCUMENT> <DOCUMENT> <TYPE>INFORMATION TABLE <SEQUENCE>2 <FILENAME>infotable.xml <TEXT> <XML> <?xml version="1.0" ?> <informationTable xsi:schemaLocation="http://www.sec.gov/edgar/document/thirteenf/informationtable eis_13FDocument.xsd" xmlns="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:n1="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <infoTable> <nameOfIssuer>ADVERUM BIOTECHNOLOGIES INC</nameOfIssuer> <titleOfClass>COM NEW</titleOfClass> <cusip>00773U207</cusip> <value>3715829</value> <shrsOrPrnAmt> <sshPrnamt>541666</sshPrnamt> 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