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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Cash flows from operating activities:    
Net loss $ (49,061) $ (59,787)
Adjustments to reconcile net loss to net cash used in operating activities:    
Accretion of discount on investments (1,411) (424)
Amortization of right of use assets 1,165 1,129
Impairment of right of use assets   724
Change in fair value of warrant liability (16,001)  
Loss on disposal of assets   17
Depreciation expense 786 1,165
Stock-based compensation including ESPP 6,747 10,069
Changes in operating assets and liabilities:    
Other assets 512 3,472
Accounts payable 223 (1,796)
Accrued liabilities (2,681) (3,657)
Operating lease liabilities (1,966) (1,805)
Other liabilities   46
Deferred revenue from collaborations (84) (6,650)
Deferred revenue from customers (569) 1,158
Net cash and cash equivalents used in operating activities (62,340) (56,339)
Activities in available-for-sale investments:    
Maturities of short-term investments 70,000 45,011
Purchase of short-term investments (108,149) (11)
Purchases of property and equipment (102) (12)
Net cash and cash equivalents (used in) provided by investing activities (38,251) 44,988
Cash flows from financing activities:    
Proceeds from issuance of common stock upon exercise of pre funded warrants 1  
Payments on finance lease (40) (92)
Proceeds from the ESPP purchase 297 461
Proceeds from the exercise of common stock option   23
Net cash and cash equivalents provided by financing activities 258 392
Net decrease in cash, cash equivalents, and restricted cash (100,333) (10,959)
Cash, cash equivalents, and restricted cash, beginning of period 135,774 81,462
Cash, cash equivalents, and restricted cash, end of period 35,441 70,503
Reconciliation to amounts on the Consolidated Balance Sheets:    
Cash and cash equivalents 35,331 70,429
Restricted cash 110 74
Total cash, cash equivalents, and restricted cash 35,441 70,503
Supplemental disclosures of noncash financing and investing activities:    
Mark to market adjustment for available-for-sale investments $ 32 96
Acquisition of right of use asset through operating lease obligation   1,094
Vesting of early exercised options   $ 59