Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Components of Total Loss Before Income Taxes

The components of total loss before taxes are as follows (in thousands):

	Years Ended December 31,
	2022			2021			2020
U.S.	$	(667,612	)	$	(123,201	)	$	(143,623	)
Foreign		(80,005	)		(37,037	)		(7,405	)
Total loss before taxes from continuing operations	$	(747,617	)	$	(160,238	)	$	(151,028	)

Summary of Provision for (Benefit from) Income Taxes

The provision for (benefit from) income taxes consisted of the following (in thousands):

	Years Ended December 31,
	2022			2021			2020
Current:
U.S. federal	$	—		$	—		$	203
Foreign		21,252			12,531			8,865
State and local		1,723			(604	)		1,454
Total current		22,975			11,927			10,522
Deferred:
U.S. federal		(5,431	)		1,215			(17,811	)
Foreign		(3,871	)		7,116			(699	)
State and local		(84	)		(1,418	)		(1,747	)
Total deferred		(9,386	)		6,913			(20,257	)
Provision for (benefit from) income taxes	$	13,589		$	18,840		$	(9,735	)

Component of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets and liabilities are as follows (in thousands):

	December 31,
	2022			2021
Deferred tax assets
Net operating losses	$	19,477		$	29,786
Research credits		6,791			7,446
Foreign tax credits		2,119			3,858
Accrued expenses		27,987			25,407
Basis difference in fixed and intangible assets		16,290			14,276
Deferred revenue		9,556			12,425
Capitalized R&D		63,601			48,807
Lease liability		13,310			14,158
Other tax credits		1,673			—
Gross deferred tax assets		160,804			156,163
Valuation allowance		(111,779	)		(101,529	)
Net deferred tax assets		49,025			54,634
Deferred tax liabilities
Acquired intangible assets		(45,424	)		(47,476	)
Revenue recognition		(2,292	)		(4,845	)
Right-of-use asset		(10,550	)		(13,706	)
Other		(1,562	)		(1,188	)
Gross deferred tax liabilities		(59,828	)		(67,215	)
Net deferred tax liabilities	$	(10,803	)	$	(12,581	)

Summary of Deferred Tax Assets for Tax Effects of Following Gross Tax Loss Carryforwards

As of December 31, 2022, the Company had recorded deferred tax assets for the tax effects of the following gross tax loss carryforwards (in thousands):

	Carry forward Amount		Years of Expiration
Federal	$	24,121	2027 - 2032
State (post-apportionment)	$	154,352	2023 - 2041

Schedule of Credits Available to Reduce Future Income Tax Expense

As of December 31, 2022, the Company had the following credits available to reduce future income tax expense (in thousands):

	Carry forward Amount		Years of Expiration
Federal research and development credits	$	8,644	2024 - 2042
State research and development credits	$	13,174	Indefinite

Schedule of Changes in Deferred Tax Asset Valuation Allowance

The deferred tax asset valuation allowance and changes in the deferred tax asset valuation allowance consisted of the following (in thousands):

	Years Ended December 31,
	2022			2021			2020
Balance at beginning of period	$	101,529		$	52,676		$	27,796
Charged (credited) to expenses		19,321			59,249			16,177
Charged (credited) to other accounts		(9,071	)		(10,396	)		8,703
Balance at end of period	$	111,779		$	101,529		$	52,676

Reconciliation of Statutory U.S. Federal Income Tax Rate to Company's Effective Tax

A reconciliation of the statutory U.S. federal income tax rate to the Company’s effective tax rate is as follows:

	Years Ended December 31,
	2022			2021			2020
U.S. federal statutory rate	$	(157,032	)	$	(33,650	)	$	(31,716	)
State, net of federal benefit		1,974			(258	)		(1,129	)
Stock-based compensation		2,036			(1,740	)		2,779
Executive compensation limitation		2,286			2,221			563
Research tax credit		(5,225	)		(2,321	)		(1,610	)
Foreign withholding tax		8,079			11,018			7,620
Goodwill impairment		107,831			—			—
Restructuring and transaction costs		293			—			6,161
Foreign rate differential		19,337			16,407			2,082
Foreign tax credit		(977	)		(8,928	)		(5,441	)
Change in valuation allowance		20,491			39,063			7,158
Foreign income inclusions		7,656			—			642
Unrecognized tax benefits		6,798			1,526			1,703
Change in estimates		(1,802	)		(4,674	)		—
Others		1,844			176			1,453
Total	$	13,589		$	18,840		$	(9,735	)

Reconciliation of Unrecognized Tax Benefits

The reconciliation of the Company’s unrecognized tax benefits for the years ended December 31, 2022, 2021 and 2020 is as follows (in thousands):

	Years Ended December 31,
	2022			2021			2020
Total unrecognized tax benefits at January 1	$	8,438		$	7,106		$	9,067
Changes due to mergers and transactions		1,682			(1,440	)		(3,605	)
Increases for tax positions related to the current year		8,793			1,962			958
Increases for tax positions related to prior years		444			1,303			745
Decreases for tax positions related to prior years		(3	)		(493	)		(59	)
Total unrecognized tax benefits at December 31	$	19,354		$	8,438		$	7,106