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Accrued expenses (Details) - USD ($)
Mar. 31, 2023
Dec. 31, 2022
Accrued expenses    
Professional fees $ 389,561 $ 75,012
Compensation, severance and benefits 1,728,544 1,397,977
Research and development 1,097,765 688,858
Other 185,491 196,485
Total accrued expenses $ 3,401,361 $ 2,358,332