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Trade and other payables - Schedule of accrued liabilities (Details) - USD ($)
Dec. 31, 2022
Dec. 31, 2021
Trade and other payables [abstract]    
External research and development fees $ 3,531,996 $ 3,062,844
Operational expenses 92,783 412,008
Professional and other fees 314,445 570,193
Accrued interest 409,193 364,275
Severance 0 46,026
Accrued liabilities $ 4,348,417 $ 4,455,346