Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 333-266024 and 333-258735) of UpHealth, Inc. of our report dated March 31, 2023 relating to the consolidated financial statementsas of and for the year ended December 31, 2022, which appears in this Annual Report on Form 10-K.

/s/ BPM LLP

San Jose, California

March 31, 2023