CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
OPERATING ACTIVITIES:
Net loss	$ (107,998)	$ (165,011)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	976	883
Share-based compensation expense	24,081	21,397
Acquired in-process research and development expense		5,000
Loss (gain) from equity-method investment	515	(670)
Foreign currency transaction gain	(2,976)	(923)
Other non-cash expenses	3,899	2,477
Changes in operating assets and liabilities
Accounts receivable	1,323	110
Prepaid expense and other assets	(1,858)	(2,302)
Accounts payable	5,335	(2,569)
Accrued liabilities	2,015	13,569
Deferred revenue	(53,578)	35,493
Net cash used in operating activities	(128,266)	(92,546)
INVESTING ACTIVITIES:
Acquisition of property and equipment	(3,919)	(2,288)
Net cash used in investing activities	(3,919)	(2,288)
FINANCING ACTIVITIES:
Proceeds from debt		46,599
Proceeds from exercise of stock options	962	672
Proceeds from the issuance of common stock under equity plans	411	515
Payments on debt obligations	(2,000)
Net cash used in (provided by) financing activities	(627)	47,786
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH	(132,812)	(47,048)
Cash, cash equivalents and restricted cash at beginning of the period	372,569	463,002
Cash, cash equivalents and restricted cash at end of the period	239,757	415,954
Supplemental disclosure of cash flow information
Cash paid for interest	585	514
Non-cash investing activities
Right-of-use assets acquired through operating leases	30,191	1,828
Acquisition of in-process research and development through issuance of common stock		5,000
Purchase of property and equipment in accounts payable and accrued expenses	$ 2,761	$ 60