UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-PX

Annual Report of Proxy Voting Record of

Registered Management Investment Company

Investment Company Act File Number: 811-23409

American Funds Multi-Sector Income Fund

(Exact Name of Registrant as Specified in Charter)

6455 Irvine Center Drive

Irvine, California 92618

(Address of Principal Executive Offices)

Registrant's telephone number, including area code: (213) 486-9200

Date of fiscal year end: December 31

Date of reporting period: July 1, 2020 - June 30, 2021

Steven I. Koszalka

American Funds Multi-Sector Income Fund

333 South Hope Street

Los Angeles, California 90071

(Name and Address of Agent for Service)

FORM N-PX

ICA File Number:  811-23409

Registrant Name:  American Funds Multi-Sector Income Fund

Reporting Period:  07/01/2020 - 06/30/2021

American Funds Multi-Sector Income Fund

CALIFORNIA RESOURCES CORPORATION Meeting Date:  MAY 12, 2021 Record Date:  MAR 15, 2021 Meeting Type:  ANNUAL
Ticker:  CRC Security ID:  13057Q305
Proposal No	Proposal	Proposed By	Management Recommendation	Vote Cast
1.1	Elect Director Douglas E. Brooks	Management	For	For
1.2	Elect Director Tiffany (TJ) Thom Cepak	Management	For	For
1.3	Elect Director James N. Chapman	Management	For	For
1.4	Elect Director Mark A. (Mac) McFarland	Management	For	For
1.5	Elect Director Julio M. Quintana	Management	For	For
1.6	Elect Director William B. Roby	Management	For	For
1.7	Elect Director Andrew Bremner	Management	For	For
2	Ratify KPMG LLP as Auditors	Management	For	For
3	Advisory Vote to Ratify Named Executive Officers' Compensation	Management	For	For
4	Advisory Vote on Say on Pay Frequency	Management	One Year	One Year

OASIS PETROLEUM INC. Meeting Date:  APR 28, 2021 Record Date:  MAR 05, 2021 Meeting Type:  ANNUAL
Ticker:  OAS Security ID:  674215207
Proposal No	Proposal	Proposed By	Management Recommendation	Vote Cast
1a	Elect Director Douglas E. Brooks	Management	For	For
1b	Elect Director Samantha Holroyd	Management	For	For
1c	Elect Director John Jacobi	Management	For	For
1d	Elect Director N. John Lancaster, Jr.	Management	For	For
1e	Elect Director Robert McNally	Management	For	For
1f	Elect Director Cynthia L. Walker	Management	For	For
2	Ratify PricewaterhouseCoopers LLP as Auditors	Management	For	For
3	Advisory Vote to Ratify Named Executive Officers' Compensation	Management	For	For

WHITING PETROLEUM CORPORATION Meeting Date:  MAY 11, 2021 Record Date:  MAR 16, 2021 Meeting Type:  ANNUAL
Ticker:  WLL Security ID:  966387508
Proposal No	Proposal	Proposed By	Management Recommendation	Vote Cast
1.1	Elect Director Janet L. Carrig	Management	For	For
1.2	Elect Director Susan M. Cunningham	Management	For	For
1.3	Elect Director Paul J. Korus	Management	For	For
1.4	Elect Director Kevin S. McCarthy	Management	For	For
1.5	Elect Director Lynn A. Peterson	Management	For	For
1.6	Elect Director Daniel J. Rice, IV	Management	For	For
1.7	Elect Director Anne Taylor	Management	For	For
2	Advisory Vote to Ratify Named Executive Officers' Compensation	Management	For	Against
3	Ratify Deloitte & Touche LLP as Auditor	Management	For	For

END NPX REPORT

SIGNATURE

Pursuant to the requirements of the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

AMERICAN FUNDS MULTI-SECTOR INCOME FUND

(Registrant)

By /s/ Kristine M. Nishiyama

Kristine M. Nishiyama, Principal Executive Officer

Date: August 26, 2021