Condensed Consolidated Statements of Cash Flows $ in Thousands	6 Months Ended
	Jun. 30, 2024 USD ($)	Jun. 30, 2023 USD ($)
Cash flows from operating activities:
Net loss	$ (66,375)	$ (81,667)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	18,546	17,235
Depreciation and amortization	3,298	3,202
Non-cash interest	211	198
Deferred income tax benefit	(877)	(3,683)
Changes in operating assets and liabilities:
Accounts receivable	(232)	52,358
Research and development incentives receivable	(22,575)	7,199
Prepaid expenses and other assets	(8,783)	(638)
Operating lease right-of-use assets	2,187	2,054
Accounts payable	(6,354)	21
Accrued expenses and other current liabilities	(3,626)	8,416
Operating lease liabilities	(2,382)	(1,867)
Deferred revenue	(28,671)	(15,454)
Other long-term liabilities	137	311
Net cash used in operating activities	(115,496)	(12,315)
Cash flows from investing activities:
Purchases of property and equipment	(432)	(2,376)
Net cash used in investing activities	(432)	(2,376)
Cash flows from financing activities:
Proceeds from the issuance of ADSs and non-voting ordinary shares, net of issuance costs	545,106	14,843
Proceeds from the exercise of share options and settlement of restricted share units	6,371	167
Net cash provided by financing activities	551,477	15,010
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(608)	960
Net increase in cash, cash equivalents and restricted cash	434,941	1,279
Cash, cash equivalents and restricted cash at beginning of period	526,970	339,154
Cash, cash equivalents and restricted cash at end of period	961,911	340,433
Reconciliation of cash, cash equivalents and restricted cash
Cash and cash equivalents	961,364	340,433
Restricted cash included in other assets	547
Total cash, cash equivalents and restricted cash	961,911	340,433
Supplemental disclosure of cash flow information
Cash paid for interest	1,146	1,365
Cash paid for income taxes	792	664
Equity issuance costs included in accounts payable and accrued expenses	979
Cash paid for amounts included in the measurement of operating lease liabilities	2,874	2,771
Changes in purchases of property and equipment in accounts payable and accrued expenses	$ 26	(1,401)
Advance billings on deferred revenue included in accounts receivable		45,000
Non-cash impact to right-of-use assets and operating lease liabilities		$ 4,004