Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities:
Net loss	$ (26,563)	$ (39,064)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	9,282	9,042
Depreciation and amortization	1,658	1,557
Non-cash interest	104	102
Deferred income tax benefit	(767)	(2,106)
Changes in operating assets and liabilities:
Accounts receivable		2,519
Research and development incentives receivable	(15,268)	(6,830)
Prepaid expenses and other assets	(8,390)	(1,735)
Operating lease right-of-use assets	1,085	1,009
Accounts payable	(5,923)	(2,001)
Accrued expenses and other current liabilities	(5,412)	(3,130)
Operating lease liabilities	(1,179)	(1,034)
Deferred revenue	(19,555)	(4,900)
Other long-term liabilities	59	160
Net cash used in operating activities	(70,869)	(46,411)
Cash flows from investing activities:
Purchases of property and equipment	(12)	(2,099)
Net cash used in investing activities	(12)	(2,099)
Cash flows from financing activities:
Proceeds from the issuance of ADSs, net of issuance costs		2,716
Proceeds from the exercise of share options and sale of ordinary shares	1,871	2
Net cash provided by financing activities	1,871	2,718
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(416)	453
Net decrease in cash, cash equivalents and restricted cash	(69,426)	(45,339)
Cash, cash equivalents and restricted cash at beginning of period	526,970	339,154
Cash, cash equivalents and restricted cash at end of period	457,544	293,815
Reconciliation of cash, cash equivalents and restricted cash
Cash and cash equivalents	456,997	293,815
Restricted cash included in other assets	547
Total cash, cash equivalents and restricted cash	457,544	293,815
Supplemental disclosure of cash flow information
Cash paid for interest	686	679
Cash paid for amounts included in the measurement of operating lease liabilities	1,435	1,351
Changes in purchases of property and equipment in accounts payable and accrued expenses	$ 26	(1,737)
Advance billings on deferred revenue included in accounts receivable		50,000
Non-cash impact right-of-use asset and operating lease liabilities		$ 5,849