Nature of the business and basis of presentation - Liquidity (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Cash and cash equivalents	$ 456,997	$ 293,815	$ 526,423
Gross proceeds before discounts and commissions		2,716
Proceeds from the issuance of ADSs, net of issuance costs		2,716
Offering expenses		100
Net loss	26,563	$ 39,064
Accumulated deficit	$ (538,323)		$ (511,760)
At the market offering | American Depositary Shares
Shares issued (in shares)	0	100,000
Gross proceeds before discounts and commissions		$ 2,800
Proceeds from the issuance of ADSs, net of issuance costs		2,700
Offering expenses		$ 100