<SEC-DOCUMENT>0001558370-24-004380-index.html : 20240329
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<ACCEPTANCE-DATETIME>20240329160522
ACCESSION NUMBER:		0001558370-24-004380
CONFORMED SUBMISSION TYPE:	PRE 14A
PUBLIC DOCUMENT COUNT:		17
CONFORMED PERIOD OF REPORT:	20240329
FILED AS OF DATE:		20240329
DATE AS OF CHANGE:		20240329

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		PRE 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38916
		FILM NUMBER:		24804136

	BUSINESS ADDRESS:	
		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
		STREET 2:		GRANTA PARK, GREAT ABINGTON
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
		STREET 2:		GRANTA PARK, GREAT ABINGTON
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212
</SEC-HEADER>
<DOCUMENT>
<TYPE>PRE 14A
<SEQUENCE>1
<FILENAME>tmb-20240329xpre14a.htm
<DESCRIPTION>PRE 14A
<TEXT>
Document 1 - file: tmb-20240329xpre14a.htm

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Document 2 - file: tmb-20240329xpre14a_a001.jpg

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<DOCUMENT>
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<SEQUENCE>3
<FILENAME>tmb-20240329xpre14a_a004.jpg
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<TEXT>
Document 3 - file: tmb-20240329xpre14a_a004.jpg

</DOCUMENT>
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<SEQUENCE>4
<FILENAME>tmb-20240329xpre14a_a005.jpg
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<TEXT>
Document 4 - file: tmb-20240329xpre14a_a005.jpg

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<SEQUENCE>5
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<TEXT>
Document 5 - file: tmb-20240329xpre14a_a006.jpg

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<SEQUENCE>6
<FILENAME>tmb-20240329xpre14a_a007.jpg
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<TEXT>
Document 6 - file: tmb-20240329xpre14a_a007.jpg

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<DOCUMENT>
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<SEQUENCE>7
<FILENAME>tmb-20240329xpre14a_a009.jpg
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<TEXT>
Document 7 - file: tmb-20240329xpre14a_a009.jpg

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Document 8 - file: tmb-20240329xpre14a_a010.jpg

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<SEQUENCE>9
<FILENAME>tmb-20240329xpre14a_a011.jpg
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<TEXT>
Document 9 - file: tmb-20240329xpre14a_a011.jpg

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<SEQUENCE>10
<FILENAME>tmb-20240329xpre14a_a014.jpg
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<TEXT>
Document 10 - file: tmb-20240329xpre14a_a014.jpg

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<SEQUENCE>11
<FILENAME>tmb-20240329xpre14a_a015.jpg
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Document 11 - file: tmb-20240329xpre14a_a015.jpg

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<SEQUENCE>12
<FILENAME>tmb-20240329xpre14a_a022.jpg
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<TEXT>
Document 12 - file: tmb-20240329xpre14a_a022.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>tmb-20240329xpre14a_a023.jpg
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<TEXT>
Document 13 - file: tmb-20240329xpre14a_a023.jpg

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<FILENAME>tmb-20240329xpre14a_a025.jpg
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Document 14 - file: tmb-20240329xpre14a_a025.jpg

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<FILENAME>tmb-20240329xpre14a_a029.jpg
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<TEXT>
Document 15 - file: tmb-20240329xpre14a_a029.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>16
<FILENAME>tmb-20240329xpre14a_bg001.jpg
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<TEXT>
Document 16 - file: tmb-20240329xpre14a_bg001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>17
<FILENAME>tmb-20240329xpre14a_bg002.jpg
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<TEXT>
Document 17 - file: tmb-20240329xpre14a_bg002.jpg

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