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Income taxes - Reconciliation of benefit for income taxes (Details)
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Income taxes      
Provision for (benefit from) income taxes at statutory rate 23.50% 19.00% 19.00%
(Decreases) increases resulting from:      
Federal tax credits 0.30% 0.30% 0.60%
Change in valuation allowance (14.80%) (16.80%) (27.00%)
Net losses surrendered for research credit (11.10%) (6.50%) (5.90%)
Impact of statutory rate change 2.70% 11.30% 12.10%
Impact of foreign exchange rates (0.10%) (9.90%)  
Other (1.30%) 3.90% 3.60%
Effective income tax rate (0.80%) 1.30% 2.40%