Condensed Consolidated Statements of Cash Flows $ in Thousands	9 Months Ended
	Sep. 30, 2023 USD ($)	Sep. 30, 2022 USD ($)
Cash flows from operating activities:
Net loss	$ (131,565)	$ (82,739)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	24,665	21,239
Depreciation and amortization	4,892	2,303
Non-cash interest	289	359
Deferred income tax provision (benefit)	3,588	(2,640)
Changes in operating assets and liabilities:
Accounts receivable	2,482	348
Research and development incentives receivable	2,192	(3,064)
Prepaid expenses and other assets	(4,615)	(2,137)
Operating lease rightofuse assets	3,116	2,015
Accounts payable	3,835	4,931
Accrued expenses and other current liabilities	6,084	5,495
Operating lease liabilities	(2,983)	(1,446)
Deferred revenue	74,238	(969)
Other long-term liabilities	442	503
Net cash used in operating activities	(13,340)	(55,802)
Cash flows from investing activities:
Purchases of property and equipment	(2,878)	(17,539)
Net cash used in investing activities	(2,878)	(17,539)
Cash flows from financing activities:
Proceeds from the issuance of ADSs, and non-voting ordinary shares, net of issuance costs	249,335
Proceeds from the exercise of share options and sale of ordinary shares	306	804
Net cash provided by financing activities	249,641	804
Effect of exchange rate changes on cash, cash equivalents and restricted cash	57	(4,674)
Net increase (decrease) in cash, cash equivalents and restricted cash	233,480	(77,211)
Cash, cash equivalents and restricted cash at beginning of period	339,154	438,680
Cash, cash equivalents and restricted cash at end of period	572,634	361,469
Reconciliation of cash, cash equivalents and restricted cash
Cash and cash equivalents	572,086	361,469
Restricted cash included in other assets	548
Total cash, cash equivalents and restricted cash	572,634	361,469
Supplemental disclosure of cash flow information
Cash paid for interest	2,059	2,099
Cash paid for income taxes	664	1,203
Cash paid for amounts included in the measurement of operating lease liabilities	4,188	2,245
Changes in purchases of property and equipment in accounts payable and accrued expenses	(1,689)	318
Non-cash impact right-of-use asset and operating lease liabilities	$ 3,898	$ 3,120