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Commitments and contingencies - Leases, Office and laboratory space Cambridge (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Jan. 26, 2023
Dec. 06, 2021
Sep. 30, 2023
Sep. 30, 2023
Jan. 31, 2023
Dec. 31, 2022
Mar. 31, 2022
Dec. 31, 2021
Sep. 30, 2017
Leases                  
Operating lease right-of-use assets     $ 14,597 $ 14,597   $ 13,658      
Lease liabilities     15,084 15,084          
Payments for the extended lease due remainder of fiscal year     1,394 1,394          
Office and laboratory space in Cambridge Massachusetts                  
Leases                  
Lease total contractual Term 3 years                
Renewal term         2 years        
Leases, term of contract 3 years                
Annual rent $ 2,100                
Rental payment $ 2,300                
Rent free period 2 months                
Security deposit $ 500                
Operating lease right-of-use assets 5,800                
Lease liabilities $ 5,800                
Discounted percentage for present value of lease payments 9.00%                
New Office and laboratory space in Cambridge, United Kingdom                  
Leases                  
Lease total contractual Term   10 years              
Renewal term   10 years              
Leases, term of contract   5 years              
Annual rent   $ 3,000              
Rent free period   6 months              
Security deposit   $ 0              
Operating lease right-of-use assets   11,600              
Lease liabilities   $ 11,100              
Discounted percentage for present value of lease payments   6.90%              
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge                  
Leases                  
Renewal term               5 years  
Annual rent               $ 600  
Estimated service charges payable               $ 200  
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge | General and administrative expenses                  
Leases                  
Loss on lease termination     300 300          
Office and laboratory space in Lexington, Massachusetts                  
Leases                  
Annual rent     800 800          
Security deposit                 $ 200
Discounted percentage for present value of lease payments             7.00%    
Payments for the extended lease remaining through December           $ 200      
Payments for the extended lease due remainder of fiscal year     $ 700 $ 700          
Prepaid rent                 $ 100