Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities:
Net loss	$ (81,667)	$ (54,392)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	17,235	15,871
Depreciation and amortization	3,202	1,039
Non-cash interest	198	271
Deferred income tax benefit	(3,683)	(1,616)
Changes in operating assets and liabilities:
Accounts receivable	52,358	(9,346)
Research and development incentives receivable	7,199	(6,850)
Prepaid expenses and other assets	(638)	(2,418)
Operating lease rightofuse assets	2,054	1,343
Accounts payable	21	1,341
Accrued expenses and other current liabilities	8,416	3,209
Operating lease liabilities	(1,867)	(789)
Deferred revenue	(15,454)	2,072
Other long-term liabilities	311	334
Net cash used in operating activities	(12,315)	(49,931)
Cash used in investing activities:
Purchases of property and equipment	(2,376)	(14,555)
Net cash used in investing activities	(2,376)	(14,555)
Cash flows from financing activities:
Proceeds from the issuance of ADSs, net of issuance costs	14,843
Proceeds from the exercise of share options and sale of ordinary shares	167	645
Net cash provided by financing activities	15,010	645
Effect of exchange rate changes on cash and cash equivalents	960	(2,070)
Net increase (decrease) in cash and cash equivalents	1,279	(65,911)
Cash and cash equivalents at beginning of period	339,154	438,680
Cash and cash equivalents at end of period	340,433	372,769
Supplemental disclosure of cash flow information
Cash paid for interest	1,365	1,390
Cash paid for income taxes	664	749
Cash paid for amounts included in the measurement of operating lease liabilities	2,771	1,336
Changes in purchases of property and equipment in accounts payable and accrued expenses	(1,401)	1,209
Advance billings on deferred revenue included in accounts receivable	45,000
Non-cash impact right-of-use asset and operating lease liabilities	$ 4,004	$ 3,120