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Significant agreements (Tables)
6 Months Ended
Jun. 30, 2023
Significant agreements.  
Summary of revenue recognized from collaboration arrangements The following table summarizes the revenue recognized in the Company’s condensed consolidated statements of operations and comprehensive loss from these arrangements (in thousands):

Three Months 

Six Months

Ended 

Ended 

June 30, 

June 30, 

    

2023

    

2022

    

2023

    

2022

Collaboration revenues

    

  

    

  

    

  

    

  

Ionis

2,557

2,255

5,341

4,569

Genentech

7,636

872

9,748

2,346

Dementia Discovery Fund

 

 

86

 

 

158

AstraZeneca

1,204

1,165

1,204

1,165

Total collaboration revenues

$

11,397

$

4,378

$

16,293

$

8,238

Summary of changes in the balances of the Company's contract assets and liabilities

The following table presents changes in the balances of the Company’s contract assets and liabilities (in thousands):

Beginning Balance

Impact of

Ending Balance

January 1,

Exchange

June 30,

    

2023

    

Additions

    

Deductions

    

Rates

    

2023

Contract liabilities:

  

  

  

  

  

Deferred revenue

  

  

  

  

  

Bayer collaboration deferred revenue

$

$

45,000

$

$

(543)

$

44,457

Novartis collaboration deferred revenue

50,000

1,553

51,553

Ionis collaboration deferred revenue

21,489

870

(5,341)

695

17,713

Genentech collaboration deferred revenue

39,308

(9,748)

1,554

31,114

AstraZeneca collaboration deferred revenue

 

1,076

 

 

(1,204)

128

 

Total deferred revenue

$

61,873

$

95,870

$

(16,293)

$

3,387

$

144,837

Beginning Balance

 

Impact of

Ending Balance

January 1,

Exchange

December 31,

    

2022

    

Additions

    

Deductions

    

Rates

    

2022

Contract liabilities:

  

  

  

  

  

Deferred revenue

  

  

  

  

  

Ionis collaboration deferred revenue

$

34,115

$

99

$

(9,347)

$

(3,378)

$

21,489

Genentech collaboration deferred revenue

34,436

12,000

(3,565)

(3,563)

39,308

DDF collaboration deferred revenue

 

428

 

 

(386)

 

(42)

 

AstraZeneca collaboration deferred revenue

 

2,361

 

 

(1,165)

 

(120)

 

1,076

Total deferred revenue

$

71,340

$

12,099

$

(14,463)

$

(7,103)

$

61,873

Summary of recognition of revenues as a result of changes in contract asset and contract liability balances

During the three and six months ended June 30, 2023 and 2022, the Company recognized the following revenues as a result of changes in the contract asset and the contract liability balances in the respective periods (in thousands):

Three Months Ended

Six Months Ended

June 30, 

June 30, 

2023

    

2022

2023

    

2022

Revenue recognized in the period from:

  

  

  

  

Revenue recognized based on proportional performance

$

3,927

$

3,213

$

8,823

$

7,032

Revenue recognized based on expiration of material rights

7,470

 

1,165

7,470

 

1,206

Total

$

11,397

$

4,378

$

16,293

$

8,238

Bayer Collaboration Agreement  
Significant agreements.  
Summary of allocation of transaction price to separate performance obligations Based on the relative standalone selling prices, the allocation of the transaction price to the separate performance obligations is as follows (in thousands):

Allocation of

Performance Obligations

Transaction Price

Two combined performance obligations related to the licenses and research and development services associated with radiopharmaceutical compounds directed to the first and second targets

$

14,976

Material right associated with limited substitution rights for either the first or second target

1,527

Two material rights associated with the option to progress radiopharmaceutical candidates directed to the first and second targets into further development

14,691

Two material rights associated with the option to progress a non-radiopharmaceutical compound directed to the first and second targets

8,703

Material right for the option to expand the collaboration to include a third target and the underlying additional option rights

7,603

$

47,500

Novartis Collaboration Agreement  
Significant agreements.  
Summary of allocation of transaction price to separate performance obligations Based on the relative standalone selling prices, the allocation of the transaction price to the separate performance obligations is as follows (in thousands):

Allocation of 

Performance Obligations

    

Transaction Price

Two combined performance obligations for the first and second targets

$

18,008

Two material rights associated with limited substitution rights

 

2,466

Two material rights associated with options to progress development candidates incorporating radionuclides

 

19,684

Two material rights associated with options to progress development candidates not incorporating radionuclides

9,842

$

50,000

Ionis  
Significant agreements.  
Summary of allocation of transaction price to separate performance obligations Based on the relative standalone selling price, the allocation of the transaction price to the separate performance obligations is as follows (in thousands):

Allocation of 

Performance Obligations

    

Transaction Price

Combined licenses and research and discovery performance obligation

$

34,100

Four material rights associated with credits for IND Acceptance fees

 

3,900

$

38,000

Genentech  
Significant agreements.  
Summary of allocation of transaction price to separate performance obligations Based on the relative standalone selling price, the initial allocation of the transaction price to the separate performance obligations is as follows (in thousands):

Allocation of 

Performance Obligations

    

Transaction Price

Genentech Collaboration Program #1 Performance Obligation

$

4,019

Genentech Collaboration Program #2 Performance Obligation

 

8,037

Specified Targeting Arm Material Right Arm for Genentech Collaboration Program #1

 

352

Two material rights associated with the LSR Go Option for Collaboration Programs #1 and #2

 

12,400

Material rights associated with limited substitution rights

1,187

Two material rights for Expansion Options

7,005

$

33,000

AstraZeneca  
Significant agreements.  
Summary of allocation of transaction price to separate performance obligations Based on the relative standalone selling price, the allocation of the transaction price to the separate performance obligations was as follows (in thousands):

Allocation of 

Performance Obligations

    

Transaction Price

Target Three Research License and Related Services

$

650

Target 3 Material Right

 

1,504

Target 4 Material Right

 

1,204

Target 5 Material Right

 

1,165

Target 6 Material Right

 

1,127

$

5,650