Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 340,433	$ 339,154
Accounts receivable	45,090	2,045
Prepaid expenses and other current assets	10,023	9,022
Research and development incentives receivable	12,884	19,162
Total current assets	408,430	369,383
Property and equipment, net	17,572	19,110
Operating lease right-of-use assets	16,022	13,658
Other assets	12,146	8,458
Total assets	454,170	410,609
Current liabilities:
Accounts payable	5,250	6,472
Accrued expenses and other current liabilities	37,262	26,452
Deferred revenue, current portion	29,754	20,418
Total current liabilities	72,266	53,342
Long-term debt, net of discount	30,513	30,315
Operating lease liabilities, net of current portion	11,881	10,885
Deferred revenue, net of current portion	115,083	41,455
Other longterm liabilities	4,330	3,829
Total liabilities	234,073	139,826
Commitments and contingencies (Note 11)
Shareholders' equity:
Ordinary shares, 0.01 nominal value; 59,612,613 and 57,820,181 shares authorized at June 30, 2023 and December 31, 2022, respectively; 30,585,940 and 29,873,893 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively	396	387
Additional paid-in capital	633,341	601,105
Accumulated other comprehensive (loss) income	(877)	387
Accumulated deficit	(412,763)	(331,096)
Total shareholders' equity	220,097	270,783
Total liabilities and shareholders' equity	$ 454,170	$ 410,609