Significant agreements - Ionis Share Purchase Agreement (Details) - USD ($) $ / shares in Units, $ in Thousands			12 Months Ended
	Oct. 15, 2021	Jul. 09, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate purchase price			$ 5,703	$ 290,984	$ 48,144
American Depositary Shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate purchase price	$ 201,300
Ionis Share Purchase Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate purchase price				$ 7,558
Ionis
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction price		$ 38,000	$ 38,000
Ionis | Ionis Share Purchase Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Purchase price per share		$ 38.94
Aggregate purchase price		$ 11,000
Fair value of shares held		7,600
Transaction price		$ 3,400
Ionis | Ionis Share Purchase Agreement | American Depositary Shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Purchase price per share		$ 31.11