Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Consolidated Statements of Operations and Comprehensive Loss
Collaboration revenues	$ 14,463	$ 11,697	$ 10,390
Operating expenses:
Research and development	81,609	44,880	33,149
General and administrative	49,507	32,435	29,201
Total operating expenses	131,116	77,315	62,350
Loss from operations	(116,653)	(65,618)	(51,960)
Other income (expense):
Interest income	5,756	120	683
Interest expense	(3,344)	(2,984)	(457)
Total other income (expense), net	2,412	(2,864)	226
Net loss before income tax provision	(114,241)	(68,482)	(51,734)
Benefit from income taxes	(1,524)	(1,663)	(724)
Net loss	$ (112,717)	$ (66,819)	$ (51,010)
Net loss per share, basic	$ (3.80)	$ (2.67)	$ (2.66)
Net loss per share, diluted	$ (3.80)	$ (2.67)	$ (2.66)
Weighted average ordinary shares outstanding, basic	29,660,659	25,061,734	19,145,938
Weighted average ordinary shares outstanding, diluted	29,660,659	25,061,734	19,145,938
Comprehensives loss:
Net loss	$ (112,717)	$ (66,819)	$ (51,010)
Other comprehensive income (loss):
Foreign currency translation adjustment	3,775	(195)	(1,658)
Total comprehensive loss	$ (108,942)	$ (67,014)	$ (52,668)