Net loss per share (Tables)

12 Months Ended

Dec. 31, 2022

Net loss per share

Schedule of basic and diluted net loss attributable to ordinary shareholders

Basic and diluted net loss per share was calculated as follows (in thousands, except share and per share amounts):

	Year Ended
	December 31,
	2022		2021		2020
Numerator:
Net loss	$	(112,717)	$	(66,819)	$	(51,010)
Denominator:
Weighted average ordinary shares outstanding, basic and diluted		29,660,659		25,061,734		19,145,938
Net loss per share, basic and diluted	$	(3.80)	$	(2.67)	$	(2.66)

Schedule of antidilutive securities excluded from computation of diluted net loss per share

	December 31,
	2022	2021	2020
Restricted ordinary shares	187,725	—	—
Options to purchase ordinary shares	5,898,888	4,603,486	3,736,663
	6,086,613	4,603,486	3,736,663