Net loss per share

12 Months Ended

Dec. 31, 2022

Net loss per share

Net loss per share

12. Net loss per share

Basic and diluted net loss per share was calculated as follows (in thousands, except share and per share amounts):

	Year Ended
	December 31,
	2022		2021		2020
Numerator:
Net loss	$	(112,717)	$	(66,819)	$	(51,010)
Denominator:
Weighted average ordinary shares outstanding, basic and diluted		29,660,659		25,061,734		19,145,938
Net loss per share, basic and diluted	$	(3.80)	$	(2.67)	$	(2.66)

The Company’s potentially dilutive securities, which include options to purchase ordinary shares and restricted share units for ordinary shares, have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share. Therefore, the weighted average number of ordinary shares outstanding used to calculate both basic and diluted net loss per share is the same. The Company excluded the following potentially dilutive

ordinary shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect:

	December 31,
	2022	2021	2020
Restricted ordinary shares	187,725	—	—
Options to purchase ordinary shares	5,898,888	4,603,486	3,736,663
	6,086,613	4,603,486	3,736,663