Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net loss	$ (82,739)	$ (48,782)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	21,239	9,084
Depreciation and amortization	2,303	1,002
Non-cash interest	359	347
Changes in operating assets and liabilities:
Accounts receivable	348	5,544
Research and development incentives receivable	(3,064)	1,318
Prepaid expenses and other current assets	(2,137)	(719)
Operating lease right-of-use assets	2,015	(2,024)
Other assets	(2,640)	(955)
Accounts payable	4,931	270
Accrued expenses and other current liabilities	5,495	(521)
Operating lease liabilities	(1,446)	2,123
Deferred revenue	(969)	28,473
Other long-term liabilities	503	481
Net cash used in operating activities	(55,802)	(4,359)
Cash used in investing activities:
Purchases of property and equipment	(17,539)	(963)
Net cash used in investing activities	(17,539)	(963)
Cash flows from financing activities:
Proceeds from the issuance of ADSs, net of issuance costs		102,595
Issuance of ordinary shares pursuant to the Ionis share purchase agreement		7,558
Proceeds from the exercise of share options and sale of ordinary shares	804	4,908
Proceeds from issuance of debt		15,000
Net cash provided by financing activities	804	130,061
Effect of exchange rate changes on cash and cash equivalents	(4,674)	(1,205)
Net (decrease) increase in cash and cash equivalents	(77,211)	123,534
Cash and cash equivalents at beginning of period	438,680	135,990
Cash and cash equivalents at end of period	361,469	259,524
Supplemental disclosure of cash flow information
Cash paid for interest	2,099	1,753
Cash paid for income taxes	1,203	87
Cash paid for amounts included in the measurement of operating lease liabilities	2,245	676
Purchases of property and equipment included in accounts payable and accrued expenses	318	$ 298
Non-cash impact right-of-use asset and operating lease liabilities	$ 3,120