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Significant agreements - AstraZeneca Collaboration Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
May 31, 2018
USD ($)
employee
Nov. 30, 2016
item
Sep. 30, 2022
USD ($)
Jun. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Jun. 30, 2019
USD ($)
Significant agreements.                    
Collaboration revenues     $ 3,040   $ 4,333 $ 11,278 $ 7,926      
Deferred revenue     58,140     58,140   $ 71,340 $ 35,156  
AstraZeneca                    
Significant agreements.                    
Option fee for development and exploitation rights $ 5,000                  
Research term 3 years                  
Bicycle research term 1 year                  
AstraZeneca research 2 years                  
Additional research term 12 months                  
Transaction price $ 5,700                  
Collaboration revenues     0   $ 1,127 1,165 $ 1,404      
Deferred revenue     992     992   2,361 3,756  
AstraZeneca | Development milestone                    
Significant agreements.                    
Transaction price 700                  
AstraZeneca | Development Milestone | Development milestone                    
Significant agreements.                    
Milestone payments, receivable 29,000                  
AstraZeneca | Regulatory Milestone | Regulatory milestone                    
Significant agreements.                    
Milestone payments, receivable 23,000                  
AstraZeneca | Commercial milestone | Commercial milestone                    
Significant agreements.                    
Milestone payments, receivable $ 110,000                  
AstraZeneca | Maximum                    
Significant agreements.                    
Additional research term 15 months                  
AstraZeneca | 2016 Collaboration Agreement                    
Significant agreements.                    
Biological Targets | item   2                
AstraZeneca | May 2018 Option Exercise                    
Significant agreements.                    
Number of FTE | employee 2                  
Transaction price $ 5,000   5,650     5,650       $ 6,300
AstraZeneca | May 2018 Option Exercise | Commercialization license per candidate                    
Significant agreements.                    
Customer option payment $ 8,000                  
AstraZeneca | May 2018 Option Exercise | Target Three Research License and Related Services                    
Significant agreements.                    
Transaction price     650     650        
AstraZeneca | May 2018 Option Exercise | Target 3 Material Right                    
Significant agreements.                    
Transaction price     1,504     1,504        
Collaboration revenues                 $ 1,500  
AstraZeneca | May 2018 Option Exercise | Target 4 Material Right                    
Significant agreements.                    
Transaction price     1,204     1,204        
AstraZeneca | May 2018 Option Exercise | Target 5 Material Right                    
Significant agreements.                    
Transaction price     1,165     1,165        
Collaboration revenues       $ 1,200            
AstraZeneca | May 2018 Option Exercise | Target 6 Material Right                    
Significant agreements.                    
Transaction price     $ 1,127     $ 1,127        
Collaboration revenues               $ 1,100