Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Accrued expenses and other current liabilities
Accrued employee compensation and benefits	$ 6,328	$ 6,429
Accrued external research and development expenses	7,223	3,980
Accrued professional fees	1,052	882
Current portion of operating lease liabilities	$ 2,811	$ 2,383
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]	Accrued expenses and other current liabilities	Accrued expenses and other current liabilities
Other	$ 677	$ 570
Accrued expenses and other current liabilities	$ 18,091	$ 14,244