Summary of significant accounting policies (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Summary of significant accounting policies
Accounts receivable	$ 0		$ 0		$ 1,000
Reduction of research and development related to government grant arrangements	300	$ 1,000	1,100	$ 2,900
Government grant funding remaining for future cost reimbursement	$ 1,300		$ 1,300

Amount, after allowance for credit loss, of right to consideration from customer for product sold and service rendered in normal course of business, classified as current.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 310
-SubTopic 10
-Section 45
-Paragraph 2
-URI https://asc.fasb.org/extlink&oid=124259787&loc=d3e4428-111522

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 310
-SubTopic 10
-Section 45
-Paragraph 9
-URI https://asc.fasb.org/extlink&oid=124259787&loc=d3e4531-111522

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant