Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (54,392)	$ (34,104)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	15,871	6,396
Depreciation and amortization	1,039	665
Non-cash interest	271	223
Changes in operating assets and liabilities:
Accounts receivable	(9,346)	5,544
Research and development incentives receivable	(6,850)	(4,982)
Prepaid expenses and other current assets	(2,418)	278
Operating lease rightofuse assets	1,343	(2,229)
Other assets	(1,616)	(554)
Accounts payable	1,341	2,225
Accrued expenses and other current liabilities	3,209	(603)
Operating lease liabilities	(789)	2,296
Deferred revenue	2,072	(1,549)
Other long-term liabilities	334	317
Net cash used in operating activities	(49,931)	(26,077)
Cash used in investing activities:
Purchases of property and equipment	(14,555)	(794)
Net cash used in investing activities	(14,555)	(794)
Cash flows from financing activities:
Proceeds from the issuance of ADSs, net of issuance costs		72,752
Proceeds from the exercise of share options and sale of ordinary shares	645	1,859
Proceeds from issuance of debt		15,000
Net cash provided by financing activities	645	89,611
Effect of exchange rate changes on cash and cash equivalents	(2,070)	8
Net (decrease) increase in cash and cash equivalents	(65,911)	62,748
Cash and cash equivalents at beginning of period	438,680	135,990
Cash and cash equivalents at end of period	372,769	198,738
Supplemental disclosure of cash flow information
Cash paid for interest	1,390	1,074
Cash paid for income taxes	749	53
Cash paid for amounts included in the measurement of operating lease liabilities	1,336	200
Purchases of property and equipment included in accounts payable and accrued expenses	1,209	$ 36
Non-cash impact right-of-use asset and operating lease liabilities	$ 3,120