Commitments and Contingencies - Leases, Office and laboratory space Cambridge (Details) - USD ($) $ in Thousands	Dec. 06, 2021	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Oct. 31, 2017	Sep. 30, 2017
Leases
Operating lease right-of-use assets		$ 15,076		$ 14,666
Lease liabilities		15,401
Remainder of 2022		1,867
2023		3,981
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge
Leases
Leases, term of contract	10 years
Leases term of contract, non cancelable	5 years
Renewal term	10 years				5 years
Annual rent	$ 3,000			600	$ 500
Rent free period	6 months
Security deposit	$ 0
Operating lease right-of-use assets	11,600
Lease liabilities	$ 11,100
Discounted percentage for present value of lease payments	6.90%				7.70%
Estimated service charges payable				$ 200
Office and laboratory space in Lexington, Massachusetts
Leases
Annual rent		800
Security deposit						$ 200
Prepaid rent						$ 100
Discounted percentage for present value of lease payments			7.00%
Remainder of 2022		200
2023		$ 700